摘要
目的 建立测定药品包装用铝箔中铅含量的分析方法.方法 通过筛选消解用酸、优化样品前处理和ICP-MS分析条件,建立测定药用铝箔中铅含量的微波消解-ICP-MS分析方法.结果 铅在0～100 ng·mL-1范围内线性关系良好.方法检出限为0.09 ng· mL-1,加样回收率为94.6％,RSD为6.16％.结论 本方法可准确测定药品包装用铝箔中铅元素的含量.
Objective To develop a method for the determination of lead in aluminum foil packages for medicine. Methods The method of closed-vessel microwave digestion with inductively coupled plasma-mass spectrometry （ICP-MS） was developed through selecting nitric acid solutions, optimizing sample preparation and operating conditions for the ICP-MS instrument. Results High value of correlation coefficient was obtained from the aqueous standard curve （ranging from 0-100 ng · mL^-1）, implying that the concentration was highly correlated with the response. The limit of detection for the method was calculated to be 0.09ng · mL^-1. The average recovery was 94. 6% and the average RSD was 6. 16%. Conclusion The method was found to have good accuracy for the determination of lead in aluminum foil packges.
出处
《中国药事》
CAS
2013年第11期1189-1191,共3页
Chinese Pharmaceutical Affairs
基金
中国食品药品检定研究院中青年发展研究基金资助(编号2011A6)
关键词
微波消解
电感耦合等离子体质谱法
铅
药品包装用铝箔
microwave digestion
inductively coupled plasma-mass spectrometry
lead
aluminum foil packages for medicine
