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12-羟基二十碳四烯酸与细胞增殖及凋亡关系研究进展 被引量：3

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摘要 细胞维持正常增殖需要体内复杂而精密的调控，其中细胞内信号转导是极其重要的一方面，若细胞内的信号转导调控失调导致细胞恶性增殖就会形成肿瘤。众多研究表明，花生四烯酸的代谢产物12-羟基二十碳四烯酸（12-HETE）与正常细胞及癌变细胞的增殖、迁移密切相关。大多数肿瘤细胞都可产生12-HETE，在肿瘤发生时，较高的12-HETE浓度是重要的信号分子，并在多条信号途径中起重要作用。本文现就12-HETE与细胞增殖及凋亡关系的研究进展作一综述。
作者 孙吉君 宋宗明
机构地区 温州医科大学附属眼视光医院
出处 《浙江医学》 CAS 2013年第20期1856-1859,共4页 Zhejiang Medical Journal
关键词 羟基二十碳四烯酸 细胞增殖 凋亡 细胞内信号转导 细胞恶性增殖 肿瘤细胞 花生四烯酸 癌变细胞
分类号 R363 [医药卫生—病理学]
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参考文献45

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二级参考文献21

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浙江医学
2013年 第20期

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