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Epibatidine的全合成研究进展 被引量:1

Progress on Total Synthesis of Epibatidine
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摘要 概述了 Epibatidine全合成研究的进展。全文分四部分 :( 1) Epibatidine的发现和结构的确定 ;( 2 ) Epibatidine的全合成研究 ;( 3)氮杂双环的合成 ;( 4 ) Epibatidine的全合成研究进展。参考文献34篇。 The progress on the total synthesis of epibatidine was reviewed with 34 references. It consists of four parts: the discovery of epibatidine and the determination of its structure; the back synthesis of epibatidine; the synthesis of azobicyclic compounds; the total synthesis epibatidine.
出处 《合成化学》 CAS CSCD 2000年第6期486-492,共7页 Chinese Journal of Synthetic Chemistry
关键词 EPIBATIDINE 全合成 生物碱 氮杂双环 镇痛药 Total synthesis, Epibatidine, Medicine, Review.4
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参考文献5

  • 1Feng Ling,J Med Chem,1997年,40卷,2293页
  • 2Zhang H M,Tetra Lett,1997年,38卷,5619页
  • 3Xu S,Tetra Lett,1996年,37卷,1463页
  • 4Li T C,Bioorg Med Chem Lett,1993年,3卷,2759页
  • 5Dao F H,Tetra Lett,1993年,34卷,44页

同被引文献20

  • 1SPANDE T F, EDWARDS H M, YEH H J, et al. Epibatidine : A Novel (Chloropyridyl) - azabicycloheptane with potent Analgesic Activity from an Ecuadoran Poison Frog[J]. J. Am. Chem. Soc.. 1992. 114. 3475.
  • 2WATI' A P, VERRiER H M, O'CONNOR D. Resolution of synthetic ( + ) - and( - ) - Epibatidine by chiral high performance liquid chromatography and identification of the natural isomer[ J]. Liq. Chromatogr. , 1994, 17: 1257.
  • 3FLETCHER S R, BAKER R, CHAMBERS M S, et al. Regioselectivity in the Palladium - Catalyzed Addition of Carbon Nucleophiles to Dihydropyran Derivatives [ J ]. J. Org. Chem. , 1994, 59 : 1771.
  • 4OLIVO H F, HEMENWAY M S. Recent Syntheses of Epibatidine[J]. Org. Prep. Proced. Int. , 2002, 34: 1.
  • 5COREY E J, LOH T R. Stereocontrolled Total Synthesis of ( + ) - and ( - ) -Epibatidine[J]. J. Org. Chem. , 1993, 58:5600 - 5602.
  • 6AOYAGI S, TANAKA R, KIBAYASHI C. Total Synthesis of ( - ) - Epibatidine Using an Asymmetric Diels - Alder Reaction with a Chiral N - Acylnitroso Dienophile[ J]. J. Org. Chem. , 1998, 63 : 8397 - 8406.
  • 7AOYAGI S, TANAKA R, KIBAYASHI C. Asymmetric Total Synthesis of ( - ) -Epibatidine[J]. Tetrahedron Lett. , 1998,39:4513-4516.
  • 8HOASHI Y, YABUTA T and TAKEMOTO Y. Asymmetric Synthesis of ( - ) - Epibatidine [ J ]. Tetrahedron Lett. , 2004, 45 :9185 -9188.
  • 9TACHIHARA T H, WATANABE, KITAHARA T. Formal Total Synthesis of both Enantiomers of Epibatidine [ J ]. Heterocycles, 2002, 57(5) : 781 -785.
  • 10DERRICK L, CLIVE J, VINCE S C. Formal Synthesis of Natural Epibatidine and of its Enantiomer[ J]. Tetrahedron Lett. ,1998, 39 : 4789 - 4792.

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