产前超声检查胎儿侧脑室增宽的临床意义

Clinical significance of fetal lateral ventriculomegaly with prenatal ultrasonography

目的 探讨产前超声检测胎儿侧脑室增宽的临床意义. 方法 对孕20～ 41周的孕妇进行胎儿系统筛查,选择侧脑室＞10 mm的胎儿,每3～4周进行1次超声检查,观察侧脑室的动态变化及其他异常情况,进行染色体及病毒学检查,直至足月分娩,并随访至1岁. 结果 共检出133例侧脑室增宽的胎儿,其中轻度增宽的胎儿（10 mm＜侧脑室≤12 mm）79例；77例自行消退,预后良好；2例因染色体异常引产.中度增宽的胎儿（12 mm＜侧脑室≤15 mm）43例；25例自行消退,预后良好；4例宫内缺氧或发育迟缓,3例预后良好；12例因染色体异常或巨细胞病毒感染或合并其他畸形引产；2例侧脑室进行性增宽,最终因＞15 mm引产.重度增宽的胎儿（15 mm＜侧脑室）11例；9例合并其他畸形胎儿引产；2例孕至足月,其中1例出生后出现脑瘫,1例出生后智力和生长发育明显低于同龄儿. 结论 对侧脑室轻中度增宽的胎儿进行动态观察,并进一步进行染色体和病毒学检查,不合并其他畸形的胎儿妊娠结局良好,重度侧脑室增宽及合并其他畸形的胎儿,其妊娠结局不良.

Objetive To study the clinical significance of fetal lateral ventriculomegaly with prenatal ultrasonography.Methods Prenatal uhrasonography was performed on women at 20-41 weeks＇gestation.The fetal with lateral ventricular width ＞ 10 mm were included in this study.The changes of fetal lateral ventricular width and the associated anomalies were observed regularly every 3 ～ 4 weeks and Chromosome and Virology were checked until fetal birth.The live infants were followed up regularly until 1 years.Results 133 fetal with lateral ventriculomegaly were detected.Mild broadening of fetus （10 mm ＜ lateral ventricles≤ 12 mm） is 79 cases ;77 cases of spontaneous regression,the prognosis is good; 2 cases of chromosome anomaly induced labor.Moderate broadening of fetus （12 mm ＜ lateral ventricles ≤ 15 mm） is 43 cases; 25 cases of spontaneous regression,the prognosis is good;Among 4 cases of intrauterine hypoxia or growth retardation,3 cases of the prognosis is good; 12 cases with chromosomal abnormality or cytomegalovirus infection or associated with other malformations induced labor.2 cases of lateral ventricle were widened,the final because of ＞ 15 mm induced labor.Severe broadening of the fetus （mm 15 ＜ lateral ventricles） is 11 cases ; 9 cases associated with other malformations induced labor;2 cases were born after pregnancy to term,1 cases is cerebral palsy and 1 cases after birth,postnatal intelligence and growth was significantly lower than the same age children.Conclusion The lateral ventricle mild to moderate broadening fetus were observed dynamically and were checked chromosome and virological,No other malformation fetus have good pregnancy outcome,Severe lateral ventriculomegaly and with other malformations of the fetus,have adverse pregnancy outcome.