女性原发性生殖道恶性黑色素瘤20例临床病理分析

Clinicopathological Analysis of 20 Cases of Primary Malignant Melanoma of Female Genital Tract

探讨女性生殖道恶性黑色素瘤（MM）的临床病理特点、治疗及预后.对20例女性生殖道MM临床资料进行回顾性分析,显示女性生殖道MM占女性生殖道恶性肿瘤的0.53%,20例患者平均年龄（55.2±10.5）岁,绝经者占60%;HMB45、Melen-A、S-100阳性患者分别占92.3%、76.9%、69.2%;随访时间3个月～70个月,随访率70%,随访期间死亡率为42.9%;生存≥1年者100%,生存≥2年者63.6%,生存≥5年者9.1%.故女性生殖道MM发病率低,预后差,HMB45、Melen-A、S-100有助于病理诊断,手术是主要的治疗手段.

To investigate the clinieopathologieal features, treatment and prognosis of primary malignant melanoma （MM）of female genital tract. The clinical data of 20 cases of female genital tract MM were analyzed retrospectively. Primary female genital tract MM made up 0. 53% of all the cancers of female genital track. The mean age of the patients was 55.2±10.5 years and 60% of them was post-menopause women. HMB45 were positive in 92. 3%, Metan-A were positive in 76.9% and s-100 protein were positive in 69.2% of the patient. The follow-up rate was 70%, and the death rate during the follow-up period was 42.9 %. The patients were survival more than one year account for 100 % , two years for 63.6 and five years for 9.1 %. Female genital tract MM is a extremely rare neoplasm with poor prognosis. Immunohistochemis- try is conductive to the pathological diagnosis. The most popular treatment mode appears to be surgery.