2010~2013年成都医学院附院细菌耐药性监测

Drug Resistance Surveillance of Common Bacteria in a Hospital Between 2010 and 2013 Years

目的分析成都医学院第一附属医院临床常见细菌对常用抗菌药物的耐药性。方法采用法国生物一梅里埃ATB测试仪和补充的药敏纸片对该医院临床分离菌进行细菌药物敏感试验。结果2010年1月～2013年10月临床分离菌共6514株，革兰阴性菌4981株，革兰阳性菌1533株。在各类细菌中，主要分离菌为大肠埃希菌、肺炎克雷伯茵肺炎亚种、鲍曼不动杆菌、铜绿假单胞菌、金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌、肺炎链球菌、屎肠球菌和粪肠球菌。在革兰阴性菌中，肠杆菌科细菌对碳青霉烯类药物有较高的敏感性，非发酵菌对多粘菌素E保持高度敏感。在革兰阳性菌中，万古霉素抗菌活性最高。结论定期分析该院细菌的耐药性，为临床治疗和预防细菌感染提供依据。

Objective The drug resistance of clinical common bacteria was analysed in the First Affiliated Hospital of Chengdu Medical College. Methods The drug sensitivity tests of bacteria which were isolated from the hospital were made by the ATB and K-B test. Results A total of 6 514 clinical isolates were collected from January 2010 to October 2013, of which gram-negative bacteria accounted {or 4 981, gram-positive bacteria accounted {or 1 533. In all kinds of bacteria,the main isolated bacteria were Escherichia coli,Klebsiella pneumoniae,Acinetobaeter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus,Streptococcus pneumoniae, Enterococcus {aecium and Enterococcus {aecalis. In gram-negative bacteria, Enterobaeteriaceae are highly sensitive to Carbapenems, non fermentation bacteria to polymyxin E remain high sensitivity. In gram-positive bacteria, antimicrobial activity of Vancomycin was the highest. Currently, many drugs have good antimierobial activity. Conclusion To provid the basis for clinical treatment and prevention of bacterial infection,the drug resistance of the bacteria should be analysed regularly.