高盐诱导幽门螺杆菌致蒙古沙土鼠胃部病变的研究

The Effect of High Salt-Induced H.pylori on the Mongolian Gerbils Gastric Mucosa

目的探讨高盐环境诱导幽门螺杆菌(H.pylori)菌株对蒙古沙土鼠(MGs)胃黏膜的损伤作用。方法将90只雄性SPF级MGs,随机分成对照组(n=30只)、H.pylori组(n=30只)和高盐诱导H.pylori组(n=30只)。在灌胃后的13、26及73w分别处死MGs,行组织病理学检测。结果高盐诱导组H.pylori在MGs胃黏膜定植密度较H.pylori组明显降低(P<0.05);高盐诱导H.pylori组MGs黏膜发生慢性炎症、黏膜变性/坏死、腺体萎缩及肠化生的概率均明显低于H.pylori组,黏膜发生糜烂/溃疡及小凹上皮增生的概率明显高于H.pylori组。结论高盐诱导前后H.pylori均能导致MGS胃黏膜的损伤,高盐环境对H.pylori的致病能力会产生影响。

Objective To study the effect of high salt-induced H. pylori on the Mongolian gerbils （MGs） gastric mucosa. Methods 90 male SPF MGs were randomly divided into control group （n= 30）, H. pylori group （n=30） and high salt-induced H. pylori group （n = 30）. Animal were autopsied at 13, 26 and 73 weeks and histopathological examination was performed. Results During the experiment, H. pylori colonization density was decreased in high salt-induced H. pylori （P〈0. 05）. The incidences of chronic inflammation, degeneration, glandular atrophy and intestinal metaplasia in high salt-induced H. pylori group were significantly higher than that of H. pylori group （P〈0. 05） ,whereas the incidence of ulcer and epithelial hyperplasia was significantly lower than that of H. pylori group. Conclusion H. pylori or high salt-induced H. pylori can cause gastric mucosal damage in Mongolian gerbils,and high salt environment might have an impact on H. pylori pathogy.