中高度海拔地区世居与移居汉族慢性胃炎患者胃黏膜内MDA、SOD、XOD、NO含量比较

The Changes of Level of MDA、SOD、NO and XOD of Gastric Mucosa in Native and Migrating Han Patients with Chronic Gastritis at High Altitude

目的:探讨高原地区世居与移居汉族人群慢性胃炎胃组织内四种体液因子代谢水平差异及其意义。方法:检测高海拔地区(2 000m～2 500m)(西宁市及周边县区)世居与移居汉族人群慢性胃炎胃组织内氧自由基、脂质过氧化物丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、黄嘌呤氧化酶(XOD)水平。结果:相同海拔高度地区世居与移居汉族人群胃黏膜内MDA、SOD、NO与XOD含量或活力无明显差异。结论:平原地区人群移居高原后同样发生了严重的氧自由基与氧自由基清除剂失衡,而且高原习服后的上述因子的水平与同海拔高度地区的世居汉族相同。

Objective：To discuss the changes and its significance of metabolism of body fluid in gastric mucosa of patients with chronic gastritis at high altitude （2 000m-2 500m）. Methods：This study consisted of native and migrating high altitude Han patients, who have been living at high altitude over 20 years, with chronic gastritis each 50 objects. Level of MDA, SOD, NO and xanthine oxidase （XOD） in gastric mucosa in the both groups were meas- ured. Results：There is no a notably difference in the level of MDA, SOD, NO and XOD between native and migra- ring Hart patients at the same high altitude. Conclusions： As the adaptive changes of level of MDA, SOD, NO and XOD in migrants after migrating to high altitude for over 20 years from lowland, level of oxygen free radical and an- tioxidants were consistent between native and migrating Han patients with chronic gastritis at same high altitude.