摘要
Embryonic stern cells （ESCs） and induced pluripotent stem cells （iPSCs） hold immense promise for regenerative medicine due to their abilities to self-renew and to differentiate into all cell types. This unique property is controlled by a complex interplay between transcriptional factors and epigenefic regulators. Recent research indicates that the epigenetic role of non-coding RNAs （ncRNAs） is an integral component of this regulatory network. This report will summarize findings that focus on two classes of regulatory ncRNAs, microRNAs （miRNAs） and long ncRNAs （lncRNAs）, in the induction, maintenance and directed differentiation of ESCs and iPSCs. Manipulating these two important types of ncRNAs would be crucial to unlock the therapeutic and research potential of pluripotent stem cells.
Embryonic stern cells （ESCs） and induced pluripotent stem cells （iPSCs） hold immense promise for regenerative medicine due to their abilities to self-renew and to differentiate into all cell types. This unique property is controlled by a complex interplay between transcriptional factors and epigenefic regulators. Recent research indicates that the epigenetic role of non-coding RNAs （ncRNAs） is an integral component of this regulatory network. This report will summarize findings that focus on two classes of regulatory ncRNAs, microRNAs （miRNAs） and long ncRNAs （lncRNAs）, in the induction, maintenance and directed differentiation of ESCs and iPSCs. Manipulating these two important types of ncRNAs would be crucial to unlock the therapeutic and research potential of pluripotent stem cells.
基金
supported by grants from the Ministry of Science and Technology of China(Grant No.2011CB965100,2011DFA30480,2010CB944900,2010CB945000,2012CB966603,2011CBA01100 and 2013CB967401)
the National Natural Science Foundation of China(Grant No.31210103905,91219305,31201107,31101061,81170499,31071306,31000378 and 31171432)
the Science and Technology Commission of Shanghai Municipality(Grant No.12ZR1450900,11ZR1438500 and 11XD1405300)
Ministry of Education of China(Grant No.IRT1168 and 20110072110039)
supported by Fundamental Research Funds for the Central Universities(Grant No.2000219066,2000219067 and 2000219077)
