血清瘦素、胆囊收缩素水平对胆囊收缩功能的影响

Effect of serum leptin and cholecystokinin levels on gallbladder contraction function

目的 探讨血清瘦素、胆囊收缩素水平与胆囊收缩功能之间的关系,分析胆囊能动性在胆囊结石成因中的重要作用.方法 对120例胆囊结石（GS）患者和60例正常人群（共180例）进行胆囊收缩功能实验,测定受试人群的胆囊收缩率,依据胆囊收缩率分为胆囊收缩功能正常组（72例）和胆囊收缩功能异常组（108例）,用放射免疫法（RIA）分别检测两组人群外周血清瘦素及胆囊收缩素浓度,分析两组人群中胆囊结石的发病率及血清瘦素、胆囊收缩素水平的差异.结果 胆囊收缩功能异常组的血清瘦素、胆囊收缩素水平[（12.26±2.06） μg/L、（3.85±1.39） nmol/L]明显高于胆囊收缩功能正常组[（5.22±1.51） μg/L、（2.16±0.62）） nmol/L],差异有统计学意义（P＜0.05）；胆囊收缩功能异常组中胆囊结石患者比率（89.81％）明显高于胆囊收缩功能正常组（31.94％）,差异有统计学意义（P＜0.05）.结论 血清瘦素、胆囊收缩素水平升高是导致胆囊收缩功能下降的重要因素；胆囊能动性下降在胆囊结石形成中起重要作用.

Objective To investigate the correlation between serum leptin and cholecystokinin （CCK） levels and gallbladder contraction function, and the important role of gallbladder motility in gall stone formation. Methods 120 cases of gallstone patients and 60 normal controls （ 180 cases） were sub jected to gallbladder contraction function experiment. Gallbladder contraction rate was tested, and two groups were set up ： normal gallbladder contraction function group and abnormal gallbladder contraction func tion group. Radioimmunoassay was used to measure the peripheral serum leptin and CCK levels, and the differences in the occurrence of gallstone, serum leptin and CCK levels in the two group were analyzed. Re- suits The levels of serum leptin and CCK in abnormal gallbladder contraction function group [ （ 12. 26 ± 2. 06） μg/L and （3.85 ±1.39） nmol/L] were significantly higher than in normal gallbladder contraction function group [ （5.22 ± 1.51 ） μg/L and （2. 16 ± 0.62 ） nmol/L] with the difference being statistically significant （P 〈 0.05 ）. The ratio of patients with gallbladder gallstone in abnormal gallbaldder contraction function of patients with abnormal gallbladder contraction function group （89. 81% ） was significantly high er than that in normal gallbladder contraction function group （31.94%, P 〈 0. 05 ）. Conclusion （ 1 ） The increased serum leptin and CCK are important factors leading to the decreased gallbladder contraction func tion. （2） The decreased gallbladder motility plays an important role in the formation of gallbladder stones.