膜联蛋白A2和骨桥蛋白在乳腺癌组织的达及其与乳腺癌生物学行为的关系

Relationship of Annexin A2 and osteopontin expression with biological behaviors of breast carcinoma

目的 观察膜联蛋白A2（Annexin A2）和骨桥蛋白（OPN）在乳腺癌组织中的表达,探讨两者与乳腺癌发生发展的关系.方法 应用免疫组织化学技术检测50例乳腺癌组织和癌旁组织中Annexin A2和OPN的表达水平,并分析两者与乳腺癌生物学行为的关系.结果 Annexin A2在乳腺癌组织中呈高表达（82.00％）,在癌旁组织呈低表达（36.00％）,两者比较差异有统计学意义（P＜0.01）,Annexin A2表达水平与乳腺癌组织学分级、TNM分期、淋巴结转移有关（P＜0.01）；OPN在乳腺癌组织中呈高表达（74.00％）,在癌旁组织呈低表达（22.00％）,两者比较差异有统计学意义（P＜0.01）,OPN表达水平与乳腺癌TNM分期、淋巴结转移有关（P＜0.05）.结论 Annexin A2和OPN的高表达可能与乳腺癌的生物学行为有关.

Objective To investigate the expression of Annexin A2 and osteopontin （OPN） in breast carcinoma tissues and its relationship with breast carcinoma development. Methods The expression of Annexin A2 and OPN was examined by using immunohistochemical method in 50 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues （5 cm distance away from the margin of breast carcinoma）. Results The overexpression rate of Annexin A2 was 82.00% in carcinoma tissues 82. 00% while 36. 00% in non-cancerous adjacent breast tissues. The overexpression of Annexin A2 was related to histology grade, TNM stage and lymph node metastasis of breast carcinoma （P 〈 0. 05）. The overexpres- sion of OPN was high in carcinoma tissues （74. 00% ） while low in non-cancerous adjacent breast tissues （22. 00% ）. There was a close correlation between the expression of OPN and TNM stage and lymph node metastasis in breast carcinoma （ P 〈 0. 05 ）. Conclusion The overexpression of Annexin A2 and OPN could participate in the biological behaviors of breast carcinoma.