Wnt3a在肌源性干细胞分化为神经元样细胞中的作用
摘要
肌源性干细胞(MDSCs)是从骨骼肌分离出的多能干细胞,在特定诱导条伺下可分化为多种细胞,本实验旨在观癫MDSCs在被诱导分化为神经元样细胞雕过程中Wnt3a和Wnt5a的表达差异,拐讨两者在这一过程中所发挥的作用。
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2013年第11期2463-2463,共1页
Chinese Journal of Experimental Surgery
参考文献2
-
1Wilschut KJ,Jaksani S,Van Den Dolder J,et al.Isolation and characterization of por-cine adult muscle-derived progenitor cells.J Cell Biochem,2008,105:1228-1239.
-
2郭占鹏,梅晰凡,李全双,袁亚江,王岩松,张赫,刘世琼.大鼠乳鼠肌源性干细胞体外诱导分化为神经样细胞[J].解剖学杂志,2010,33(2):211-213. 被引量:4
二级参考文献11
-
1Kang S B,Lee H N,Lee J Y,et al.Sphincter contractility after muscle-derived stem cells autograft into the cryoinjured anal sphincters of rats[J].Dis Colon Rectum,2008,51(9):1367-1373.
-
2Matsumoto T,Cooper G M,Gharaibeh B,et al.Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1[J].Arthritis Rheum,2009,60(5):1390-1405.
-
3Tamaki T,Okada Y,Uchiyama Y,et al.Synchronized reconstitution of muscle Wbers,peripheral nerves and blood vessels by murine skeletal muscle-derived CD34-/45-cells[J].Histochem Cell Biol,2007,128(4):349-360.
-
4Park J S,Kim S,Han D K,et al.Isolation of neural precursor cells from skeletal muscle tissues and their differentiation into neuron-like cells[J].Exp Mol Med,2007,39(4):483-490.
-
5Danisovic L,Varga I,Polak S,et al.Morphology of in vitro expanded human muscle-derived stem cells[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2008,152(2):235-238.
-
6Habich A,Jurga M,Markiewicz I,et al.Early appearance of stem/progenitor cells with neural-like characteristics in human cord blood mononuclear fraction cultured in vitro[J].Exp Hematol,2006,34(7):914-925.
-
7Arsic N,Mamaeva D,Lamb N J,et al.Muscle-derived stem cells isolated as non-adherent population give rise to cardiac,skeletal muscle and neural lineages[J].Exp Cell Res,2008,314(6):1266-1280.
-
8Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J].Cell,2009,131(5):861-872.
-
9Lavasani M,Lu A,Peng H,et al.Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle[J].Hum Gene Ther,2006,17(2):180-192.
-
10Matsuda R,Yoshikawa M,Kimura H,et al.Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development[J].Cell Transplant,2009,18(1):39-54.
共引文献3
-
1张学普,吕刚,梅晰凡,张晓健.5-溴脱氧尿嘧啶核苷体外标记肌源性干细胞:最佳浓度及时间[J].中国组织工程研究与临床康复,2010,14(45):8407-8410. 被引量:2
-
2郭占鹏,梅晰凡,袁亚江,张赫,李全双.Detla1基因在肌源性干细胞分化为神经样细胞过程中的表达[J].解剖学杂志,2011,34(5):641-643. 被引量:2
-
3Xifan Mei,Chang Liu,Zhanpeng Guo,Yajiang Yuan,Shiqiang Fang,Yansong Wang,Yue Guo,Jinhao Zeng.Negative effects of Notch1 on the differentiation of muscle-derived stem cells into neuronal-like cells[J].Neural Regeneration Research,2011,6(31):2414-2418. 被引量:1
-
1郭子宽,刘晓丹,候春梅,李秀森,毛宁.人骨髓间充质干细胞体外分化为神经元样细胞[J].中国实验血液学杂志,2001,9(1):91-92. 被引量:12
-
2王浩.干细胞分化为胰腺β细胞研究进展[J].第三军医大学学报,2002,25(B11):18-20.
-
3乳鼠肌源性干细胞向许旺样细胞的诱导分化[J].中国组织工程研究,2013,17(10).
-
4文涵.经小鼠的干细胞分化可成功生成脑神经细胞[J].国外医学情报,2004,25(5):40-40.
-
5翁雨雄,陈燕花,彭云龙,李涛,刘娟,陈振兵,劳杰.丹参抑制骨骼肌肌源性干细胞成纤维样分化作用的研究[J].中华手外科杂志,2011,27(3):172-175. 被引量:4
-
6姚启盛,陈从波,王晓康,杨勇,龚小新,黄力,王黎,杨二江,刘正清.组织工程化肌源性干细胞治疗压力性尿失禁可行性的初步实验研究[J].生物医学工程与临床,2011,15(2):121-124. 被引量:4
-
7张向群,王新平,张文治.骨髓间充质干细胞治疗脑梗死的研究进展[J].国际脑血管病杂志,2007,15(8):603-606. 被引量:2
-
8赵洪昌,赵文静,刘薇,叶冬霞.体外定向诱导脐血间充质干细胞分化为心肌样细胞[J].中国实验诊断学,2012,16(9):1547-1549.
-
9张燕青,曾园山,张静,丁英,闫清,陈穗君.体外培养的嗅鞘细胞能够促进骨髓间充质干细胞分化为神经元样细胞[J].中国神经精神疾病杂志,2007,33(10):612-614. 被引量:6
-
10蔡颖,俞国松,邢雪松.Notch信号通路与干细胞分化及其相关疾病研究进展[J].沈阳医学院学报,2013,15(1):56-57. 被引量:3