人免疫球蛋白联合甲强龙治疗支原体肺炎合并EB病毒感染患者的临床疗效

Clinical efficacy of human immunoglobulin combined with methylprednisolone in treatment of Mycoplasma pneumonia complicated with EB virus infection

目的探讨人免疫球蛋白联合甲强龙对支原体肺炎合并EB病毒感染患儿的临床疗效,为临床治疗提供可靠依据。方法 128例合并EB病毒感染的支原体肺炎患儿按分层随机分组法分为两组,对照组63例患儿接受常规治疗,观察组65例患儿在对照组的基础上接受人免疫球蛋白联合甲强龙静脉滴注治疗。结果观察组退热时间(2.31±0.27)d、肺部啰音消失时间(6.89±0.45)d、咳嗽消失时间(8.56±2.34)d、住院时间(14.33±1.54)d,对照组依次为(5.02±0.64)、(10.57±0.71)、(14.66±1.47)、(23.27±3.38)d,观察组治疗优于对照组(P<0.05);观察组患儿的血清TNF-α、CRP、IL-6、IL-8值低于对照组(P<0.05),观察组患儿出现心肌酶异常、肝功能异常、肺不张、胸腔积液的并发症少于对照组(P<0.05)。结论人免疫球蛋白联合甲强龙对支原体肺炎合并EB病毒感染患儿的临床疗效显著,缩短症状缓解时间,减少其他脏器损害的发生。

OBJECTIVE To investigate the clinical efficacy of human immunoglobulin combined with methylprednisolone in treatment of Mycoplasma pneumonia complicated with EB virus infection so as guide the clinical treatment. METHODS By means of the stratified randomization method, totally 128 children complicated with Mycoplasma pneumonia and EB virus infections were divided into two groups, the control group with 63 subjects accepted the conventional therapy, while the observation group with 65 subjects received the human immunoglobulin combined with methylprednisolone based on the treatment of the control group. RESULTS The cooling time was （2.31±0.27） d in the observation group, （5.02±0. 64） d in the control group; the time of disappearance of pulmonary tales was （6.89±0.45） d in the observation group, （10.57＋0.71）d in the control group; the time of cough disappearance was （8. 56±2. 34） d in the observation group, （14. 66±1. 47）d in the control group; the hospitalization duration was （14.33±1.54） d in the observation group, （23. 27±3.38）d in the control group; the therapeutic effect of the observation group was significantly better than that of the control group （P〈0.05）. The levels of serum TNF-a, CRP , IL-6, and IL-8 of the observation group were lower than those of the control group （P〈0. 05）; the incidence of the complications such as enzymes abnormalities, abnormal liver function, atelectasis, or pleural effusion was lower in the observation group than in the control group （P 〈 0. 05）. CONCLUSION The human immunoglobulin combined with methylprednisolone can achieve significant clinical efficacy in the treatment of children complicated with Mycoplasrna pneumonia and EB virus infections, shorten the remission time of symptoms, and reduce the incidence of damage of other organs.