益生菌与肠上皮细胞间相互作用和免疫调节机制研究进展

Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation

定殖于肠道的益生菌能够通过调节上皮细胞中的信号途径如NF-κB和MAPK等来上调或抑制下游途径,从而改变胃肠道的生理机能,改善胃肠道微环境,因而常被用于预防或治疗多种疾病,但其作用机制目前尚未完全阐明。本文将从益生菌调节上皮细胞炎症信号通路、刺激产生热激蛋白以及调节细胞凋亡等方面入手,对益生菌与肠道上皮细胞间相互作用机制作以简单论述。

Probiotic colonization in the intestine by regulating signaling pathways such as NF-κB and MAPK to raised or inhibit downstream pathways, then changed the physiology of the gastrointestinal tract, improve the micro-environment of the gastrointestinal tract, and were used to prevent and treat a variety of diseases, but its mechanism has not been fully understood. This review summarize the evidence about interaction between probiotics and intestinal epithelial cell, especially emphasis on its regulation of inflammatory signal pathways, stimulation of heat shock proteins, as well as the regulation of cell apoptosis, aims at supplying new theoretical base for diagnosis and treatment of intestinal disease.