4'-取代黄酮的合成研究

Synthesis of 4'-substituted flavonoids

以2-羟基苯乙酮和苯甲酰氯及其衍生物为原料,在碳酸钾催化下一步合成了相应的β-丙二酮型化合物1-(2-羟基苯基)-3-苯基-1,3-丙二酮及其衍生物,β-丙二酮用浓硫酸进一步关环后得到了黄酮母核及其4'-取代黄酮。目标化合物通过核磁共振氢谱和质谱进行了表征。本文采用正交试验对Baker-Venkataraman重排反应的合成工艺进行了优化,对β-丙二酮类化合物的关环试剂也进行了筛选和优化。

1-（ 2-Hydroxyphenyl）-3-phenylq, 3-propanedione and its derivatives were prepared from 2-hydroxyaeetophenone with benzoyl chloride in dry acetone in the presence of potassium carbonate. After 1,3-propanedione and its derivatives were treated with concentrated sulfuric acid ,the flavonoid mother nucleus and 4＇ - substituted flavonoids were afforded. The structures of the synthesized compounds were confirmed by ^1 H NMR and MS spectroscopy. The synthesis process of Baker-Venkataraman was optimized by using orthogonal design, moreover, cyclization reagent of 1,3-propanedione were optimized in the paper also.