阿奇霉素对慢性阻塞性肺病急性加重期的疗效分析

Therapeutic effects analysis of azithromycin in acute exacerbations of COPD

目的分析阿奇霉素治疗慢性阻塞性肺病急性加重期(acute exace rbations of chronic obstructive pulmonary disease,AECOPD)的临床疗效。方法选择安徽省铜陵县人民医院2012年3月至2012年9月收治的126例AECOPD住院患者,并将其随机分为两组。对照组63例,采用常规的药物治疗;观察组63例在常规药物治疗的基础上加用阿奇霉素治疗,观察两组的治疗情况。结果观察组的治疗总有效率为93.6%,对照组的治疗总有效率为71.4%。其中观察组和对照组的治疗效果比较差异有统计学意义(P<0.05)。观察组的患者治疗前后肺功能改善情况明显优于对照组患者治疗前后肺功能改善的情况,数据比较差异有统计学意义(P<0.05);而两组患者的CAT问卷调查评估比较也具有明显的差异(P<0.05),统计学有意义。结论对于AECOPD住院患者,是一种安全、有效的治疗药物,联用阿奇霉素对于延缓肺功能下降可能有一定的意义。

Objective To explore the chnical effect of Azithromycin in treatment of AECOPD. Methods Chose 126 pa- tients with AECOPD in our hospital from March. 2012 to Sep. 2012 were divided into treatment group and control group each 63 case. Patients in control group were treated by traditional drug treatment,in treatment group addad Azithromycin, clinical effect in the two group were observed. Results The total effective in treatment and control group were 93.6% and 71.4%, the difference were significant （P 〈 O. 05 ）. Pulmonary function before and after treatment in treatment group improved significantly than that of the control group, the difference were significant （ P 〈 0.05 ）. There had significant difference in comparion of questionnaires of two groups （P 〈 0.05）. Conclusion Hospitalized patients with AECOPD treated by Azithromycin has no discomfort, it is a safe and effective treatment drug, and may be have significant on dimin- ish pulmonary function.