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网膜素的研究进展 被引量：3

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摘要 网膜素的氨基末端有一个由16个氨基酸组成的高度疏水区的蛋白质分泌性信号肽,它与2型糖尿病密切相关,主要通过促进丝/苏氨酸蛋白激酶（Akt）磷酸化而增加胰岛素敏感性,影响血糖变化;抗糖尿病药物也影响网膜素的水平,已有报道,口服二甲双胍和利拉鲁肽注射治疗后可以升高血清网膜素-1的水平.网膜素通过5＇-AMP激活蛋白激酶（AMPK）介导的内皮一氧化氮合酶（eNOS）产生NO,NO抑制C-Jun N端激酶（JNK）的活化使肿瘤坏死因子-α（TNF-α）介导的环加氧酶-2 （COX-2）的产生减少,抑制炎症反应[5].网膜素还可以通过NF-κB体活化因子（RANK）途径减轻动脉的钙化[6],达到抗动脉硬化作用.国内外的研究焦点主要集中在网膜素与糖尿病、心血管及炎症性疾病的关系上,网膜素与其他脂肪细胞因子、肿瘤、骨质疏松症、高血压、肾病也相关,本文综述如下.
作者 常小女 范志宏 王瑛 丁明辉
机构地区 山西医科大学第二医院内分泌科
出处 《中国药物与临床》 CAS 2013年第11期1437-1438,共2页 Chinese Remedies & Clinics
基金 山西省科技攻关项目(20130313017-9)
关键词 肿瘤坏死因子-α 苏氨酸蛋白激酶 抗动脉硬化作用 AMP激活蛋白激酶 内皮一氧化氮合酶 氨基酸组成 2型糖尿病 胰岛素敏感性
分类号 R446.1 [医药卫生—诊断学]
  • 相关文献

参考文献20

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同被引文献30

  • 1Xiu-Hua Wang,Ling-Zhi Dou,Can Gu,Xiao-Qing Wang.Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure[J].Asian Pacific Journal of Tropical Medicine,2014,7(1):55-62. 被引量：38
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  • 3Greulich S,Chen WJ,Maxhera B,et al.Cardioprotective properties of omentin-1 in type 2 diabetes:evidence from clinical and in vitro studies[J].PLo S One,2013,8(3):e59697.
  • 4Yamawaki H,Kuramoto J,Kameshima S,et al.Omentin,a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells[J].Biochem Biophys Res Commun,2011,408(2):339-343.
  • 5Zhong X,Li X,Liu F,et al.Omentin inhibits TNF-a-induced expression of adhesion molecules in endothelial cells via ERK/NFKB pathway[J].Biochem and Biophys Res Commun,2012,425(2):401-406.
  • 6Maruyama S,Shibata R,Kikuchi R,et al.Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism[J].J Biol Chem,2012,287(1):408-417.
  • 7Liu R,Wang X,Bu P.Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome[J].Diabetes Res Clin Pract,2011,93(1):21-25.
  • 8Shibata R,Takahashi R,Kataoka Y,et al.Association of a fatderived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men[J].Hypertens Res,2011,34(12):1309-1312.
  • 9Yamawaki H,Tsubaki N,Mukohda M,et al.Omentin,a novel adipokine,induces vasodilation in rat isolated blood vessels[J].Biochem Biophys Res Commun,2010,393(4):668-672.
  • 10龚磊,白波,陈京.网膜素:一个新的脂肪因子[J].生理科学进展,2011,42(5):390-393. 被引量：9

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中国药物与临床
2013年 第11期

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