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小剂量氯胺酮联合地佐辛应用于胸科手术麻醉抑制瑞芬太尼术后痛觉过敏的临床观察 被引量：6

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摘要 瑞芬太尼为超短效μ-阿片受体激动剂,起效快,消除半衰期短,通过血浆和组织中非特异性酯酶代谢,不依赖于肝肾,用于老年人和肝肾功能不良的患者,无需担心苏醒延迟,为较理想的阿片类药物.研究发现该药和其他阿片类药物一样,亦可引起痛觉过敏.阿片诱发的痛觉过敏（OIH）增加痛觉感知,产生异常疼痛,降低药物的镇痛效果,影响术后镇痛治疗.非特异性的N-甲基-D-天冬氨酸（NMDA）受体拮抗剂氯胺酮在受体水平可拮抗瑞芬太尼所致的OIH,在一般性手术中确实可有效预防瑞芬太尼所致的OIH.地佐辛是苯吗啡烷类衍生物,主要激动κ受体,肌肉注射后30 min起效,也对瑞芬太尼所致的OIH预防作用.本研究拟评价单独和联合使用两者对瑞芬太尼麻醉后导致的痛觉过敏的影响.
作者 朱毅 程桥 武毅彬
机构地区 山西医科大学附属肿瘤医院麻醉科
出处 《中国药物与临床》 CAS 2013年第11期1469-1470,共2页 Chinese Remedies & Clinics
关键词 小剂量氯胺酮 瑞芬太尼 痛觉过敏 麻醉后 临床观察 胸科手术 N-甲基-D-天冬氨酸 阿片受体激动剂
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献6

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二级参考文献26

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共引文献17

同被引文献54

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引证文献6

二级引证文献19

中国药物与临床
2013年 第11期

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