急性脑梗死患者血小板参数的研究

Platelet Parameters in Patients with Acute Cerebral Infarction

目的研究急性脑梗死患者的血小板参数、纤维蛋白原（Fh）含量的变化，并探讨其临床意义。方法用SysmexXE-2100全自动血球分析仪、SysmexCA-70001全自动凝血仪分别测定182例脑梗死急性期患者与135例健康对照的血小板参数及纤维蛋白原（Fb）含量。结果急性脑梗死患者血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）和Fb含量均显著高于对照组（P〈0．01），血小板压积（PCT）差异无统计学意义（P〉0．05）。梗死灶直径〉5em的患者与梗死灶直径≤5cm的患者的PLT、MPV和PDW比较，差异均有统计学意义（P〈0．01），PCT差异无统计学意义（P〉0．05）。结论观察急性脑梗死患者血小板参数和Fb含量的变化，对脑梗死的预防、治疗以及合理用药等方面具有重要的临床意义。

Objective To study the changes of platelet parameters and fibrinogen（Fb） contents in patients with acute cerebral infarction,and explore its clinical significance. Methods Sysmex XE -2100 automatic blood cell ana- lyzer and Sysmex CA -70001 automatic coagulometer were used to measure platelet parameters and Fb contents in 182 patients with acute cerebral infarction and 135 healthy controls. Results The platelet count（ PLT）, mean platelet vol- ume （ MPV ）, platelet distribution width （PDW）and Fb levels in patients with acute cerebral infarction were significant- ly higher than those in control group（P 〈 0.01 ）. There was no significant difference in thrombocytocrit （PCT） between two groups（ P 〉 O. 05 ）. There were significant differences in PLT, MPV and PDW between patients with infarction di- ameter 〉 5 cm and patients with infarct diameter ~〈5 cm（ P 〈 0.01 ）. There was no significant difference in PCT be- tween two groups （ P 〉 0.05 ）. Conclusion There is important clinical significance in observing changes of platelet parameters and Fb contents in patients with acute cerebral infarction,which is significant to prevention, treatment and rational drag use.