80例成人持续性变应性鼻炎治疗前后生活质量评估

Quality of life assessment of 80 cases of persistent allergic rhinitis in adults before and after treatment

目的探讨尘螨所致持续性变应性鼻炎（PAR）成年患者生活质量（QOL）状况，及其经标准化尘螨变应原特异性免疫治疗（SIT）或药物治疗前、后QOL的改变。方法对2011年4～8月该院确诊的PAR患者行变应原皮肤点刺试验（SPT），挑选对尘螨过敏的成年患者80例，随机分为SIT组和药物治疗组，每组各40例，在治疗6个月前、后给予鼻结膜炎生活质量调查问卷（RQLQ）量表进行问卷调查；选取40例在该院健康体检的无变应性疾病者作为对照组并予RQLQ量表进行问卷调查。比较PAR患者与对照组的Q（）I。和PAR患者治疗前、后QOL的变化及两种治疗方法对QOL影响的差异。结果PAR患者的QOL在RQI．Q量表的各个维度及总分方面均高于时照组（P％0．05），其中在鼻部症状方面受到的影响最为明显。PAR患者RQLQ备维度的积分治疗后均较治疗前下降（P〈0．05），且SIT组RQLQ各维积分均低于药物治疗组（P〈0．05）。结论成年PAR患者，经S1T或药物治疗后，其QOL较治疗前改善，且经SIT治疗的患者QOL改善更明显。

Objective To explore the health-relate quality of life（QOL） status of adult persistent allergic rhinitis （PAR）the change of QOL of pro-post specific immunotherapy （SIT） and pharmacotherapy. Methods Skin prick tests（SPT） were performed on PAR patients. According to the results,80 adult cases that were allergic to dermatophagoides were enrolled in ENT outpatient clinic of affiliated hospital of Nantong University from April to August 2011. The patients were randomly allocated to receive either specific immunotherapy（n = 40） or pharmacotherapy （n = 40）, all of them were given RQLQ before and after half-year treatments40 cases without any allergic diseases were chosen from ENT in-patient department, and were given RQLQ. The scores of previous treatment of the PAR group were compared with health control group, then compared with the scores of post-treatment, and also compared the scores of post-treatment between the immunotherapy group and pharmacotherapy group. Results The scores of the PAR patients were higher than that of health control patients in all dimensions of RQLQ（P〈0.05）,and the most troublesome problems were nasal symptoms. The scores of the patients who received SIT were evidently lower than that of pro treatment in all dimensions of RQLQ（P〈0.05） ,the scores of the patients who received medical treatment were also lower than before（P〈0.05）, and the scores of the SIT group were lower than the pharmacotherapy group（P〈0.05）. Conclusiou The QOL of adult patients with PAR was improved after SIT or drug treatment,and QOL improvement is more obvious treat by SIT.