表皮生长因子受体及其突变状况在肺癌患者外周血表达的初步研究

A Preliminary Study of Epidermal Growth Factor Receptor and Its Mutation Status in Patients with Lung Cancer in Peripheral Blood Expression

目的对表皮生长因子受体(EGFR)及其突变状况在肺癌患者外周血中的表达进行分析研究。方法随机入组在2009年1月至2012年1月间我院收治的肺癌患者62例,以及同期体检健康者60例,对其EGFR及其突变状况在外周血表达水平进行比较分析。结果肺癌组患者肿瘤EGFR及其突变的表达水平明显高于对照组,且两组差异具有统计学意义(P<0.05)。结论 EGFR及其突变水平的过度表达,可能是肺癌进程的重要标志。

Objective To analyze the expression of epidermal growth factor receptor （EGFR） and its mutation status in peripheral blood of patients with lung cancer. Methods 62 patients with lung cancer from January 2009 to January 2011, and 60 healthy subjects at the same period were selected in this study to analyze and compare the expression of EGFR and its mutation status in peripheral blood. Results The level of the expression of EGFR and its mutation status in lung cancer group was significantly higher than those in normal group （P 〈0.05）. Conclusions Over expression of EGFR and its mutation status may promote the process of lung cancer.