血管紧张素Ⅱ受体拮抗剂在高血压患者中应用的效果观察

Observation on the Effect of Angiotensin Ⅱ Receptor Blocker for Patients with Hypertension

目的探讨血管紧张素Ⅱ受体拮抗剂在高血压患者中的临床应用效果。方法选择性分析我院收治的42例高血压患者的临床资料,随机分为治疗组和对照组各21例,其中对照组患者采用吲哒帕胺治疗,治疗组在对照组的基础上加用血管紧张素Ⅱ受体拮抗剂氯沙坦进行治疗,比较两组患者治疗后的降压效果。结果治疗6个月后,对照组有效降压率为52.83%,治疗组有效降压率为85.21%,两组比较差异有统计学意义,P<0.05;治疗组总有效率为90.48%,显著高于对照组的76.19%,P<0.05;治疗过程中两组患者不良反应发生无显著性差异,P>0.05。结论血管紧张素Ⅱ受体拮抗剂治疗高血压的降压效果显著,与其它降压药物联用疗效更佳。

[ Abstract] Objective To investigate the clinical effect of angiotensin Ⅱ receptor blocker in the application of patients with flypertension. Methods Forty-two patients with hypertension in our hospital were randomly divided into the treatment group and the control group, with 21 cases in each group. The control group was treated with indapamidey, and the treatment group was taken with angiotensin Ⅱ receptor blocker （losartan） on the basis ofindapamidey therapy. The antihypertensive effects of the two groups after treatment were compared. Results After 6 months of treatment, the effective antihypertensive rate was 85.21% of treatment group, significantly higher than 52.83% of control group （P 〈0.05）. The total effective rate was 90.48% of treatment group, significantly higher than 76.19% of control group （P〈0.05）. There was no significant difference in the adverse reaction between two groups （P 〉0.05）. Conclusions The effect of angiotensin Ⅱ receptor blocker in the treatment of hypertension antihypertensive is remarkable, and it has better effect when combined with other antihypertensive drugs.