内皮-间质转化参与组织纤维化的研究进展

Research Progress of Endothelial-mesenchymal Transition in Promoting Tissue Fibrosis

组织纤维化的典型特征是成纤维细胞过度增殖和细胞外基质过度蓄积。近年来研究表明,成纤维细胞是一组高度异源的细胞群体,除了由局部静止的成纤维细胞活化而来外,还可由上皮细胞、内皮细胞、血管周细胞和骨髓起源的循环祖细胞、单核细胞等转化而来,其中源自内皮细胞的内皮-间质转化是成纤维细胞的重要来源之一,亦是纤维化发生、发展的重要机制之一。

The typical feature of tissue fibrosis is the overproliferafion of fibroblasts and the overproduc- tion of extracellular matrix. Studies in recent years indicate that the fibroblasts producing too much extracellular matrix are highly heterogenous. Its sources not only include the activated resident fibroblast, but also epithelial cell, endothelial cell, perivascular cells,circulating bone marrow-derived progenitor cells and nmnocytes. One of the most important sources is endothelial cells which undergo endothelial-mesenchymal transition （EndMT）, which is also one of the important mechanisms of fibrosis genesis and development.