摘要
越来越多的研究表明,肠屏障受损与2型糖尿病以及非特异性免疫系统激活有关。肠屏障受损可引起机体非特异性炎性激活并促进2型糖尿病的进展,2型糖尿病又可反作用于肠道而引起肠屏障受损。该文对其中的作用过程及其机制进行论述,对肠屏障受损与2型糖尿病关系的研究进展作简要的综述,并提出相应的改善措施,以期为糖尿病防治工作提供新的方向。
Increasing researches indicate that intestinal barrier damage is closely associated with type 2 diabetes mellitus（2-DM）and a general activation of the innate immune system, hnpaired intestinal barrier makes innate immune system activated and then aggravates 2-DM,which then reversely acts on the intestine and causes intestinal barrier damage. Here mainly discusses these processes and their mechanisms to analyse the relationship between intestinal barrier damage and 2-DM and gives some relevant advices, in order to provide reference for future preventive and therapeutic interventions for diabetes.
出处
《医学综述》
2013年第21期3955-3958,共4页
Medical Recapitulate
关键词
肠屏障
2型糖尿病
非特异性免疫
炎症
Intestinal barrier
Type 2 diabetes mellitus
Innate immune system
Inflammation
