维生素D及维生素D受体的研究进展

The Progress in the Studies of Vitamin D and Vitamin D Receptor

维生素D受体(VDR)是亲核蛋白,属于类固醇激素/甲状腺激素受体超家族成员,在体内主要介导维生素D的细胞作用。维生素D的主要活性代谢产物1,25-二羟胆骨化醇在体内作用广泛,与VDR结合后,除了产生经典的调节钙、磷代谢的作用外,还具有抑制增殖、促进分化、调节免疫及抑制细胞坏死、抑制肿瘤的浸润和转移等非钙调作用。近年来,活性维生素D及其衍生物的抗肿瘤作用备受注目,广泛应用于临床前抗肿瘤研究,有可能成为防治肿瘤的很有前景的药物。

Vitamin D receptor （VDR） is ribonucleoprotein and belongs to superfamily of steroid hormone/thyroid hormone receptor. The main function of VDR is mediation of vitamin D. 1,25-dihydroxycholecalciferol is active vitamin D to seduce physiological action in vivo. Active vitamin D and its analogue have the function in development, differentiation, immunoregu｜ation, inhibition of cell necrosis and inhibition of tumor invasion and metastasis in addition to calcium and phosphorus metabolic regulation. Active vitamin D and its analogue were extensively used in study of preclinical anticancer for the past few years, which may be a perspective anticancer drug.