摘要
通过计算机模拟人的心脏电生理活动,可以为经济、安全地研发心脏病治疗药物提供保障.针对这一需求,基于已建立的心肌细胞离子通道数学模型设计并实现了一种心肌细胞离子通道级仿真平台,仿真了Purkinje纤维细胞、心内膜细胞、心中间膜细胞和心外膜细胞这四种细胞的动作电位.最后根据已发表的实验数据,应用这四种细胞的数学模型对心力衰竭疾病下离子通道开放程度发生变化的病理进行了仿真实验,并且对比分析了仿真得到的心力衰竭和正常心脏情况下的结果,结果与公认实验数据相符,从而验证了该仿真平台的可靠性.
Simulating cardiac electrophysiology activities through the computer can economically and safely develop the treatment medicine of heart disease. Based on the mathematical model of myocardial cell ion channels, a myocyte ion channels functional simulation platform was achieved, including action potentials for Purkinje fibres cell, the endocardium cell, the midmyocardium cell and the epicardium cell. Pathological conditions were also simulated on the four kinds of cells in the designed system. By analyzing the normal and pathological simulation results, it is showed that the simulation results are consistent with the actual experimental data. The simulation system is reliable.
出处
《东北大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2013年第11期1533-1536,共4页
Journal of Northeastern University(Natural Science)
基金
国家自然科学基金资助项目(61179009)
关键词
心肌细胞
离子通道
心力衰竭
数学模型
心脏机能仿真
cardiac myocyte
ion channel
heart failure
mathematical model
cardiac functionalsimulation
