病毒性心肌炎患者血清SOD与心肌炎特异性标志物的相关性研究

Study on Correlation between SOD and Specific Marker in Viral Myocarditis

为探讨病毒性心肌炎患儿超氧化物歧化酶(SOD)与心肌炎特异性标志物的相关性及其临床意义,将48例小儿病毒性心肌炎患者作为实验组,以48例健康儿童作为对照组,检测实验组和对照组血清中心肌肌钙蛋白(cTnT)、超敏C反应蛋白(HS-CRP)、肌酸激酶同工酶(CK-MB)和SOD,评价其相关性。结果为:实验组cTnT、HS-CRP和CK-MB水平明显高于对照组(P<0.05),SOD的活性明显低于对照组(P<0.01);治疗3周后cTnT、HS-CRP和CK-MB水平明显降低(P<0.05),SOD的活性明显升高(P<0.01),与cTnT、HS-CRP和CK-MB水平呈负相关(P<0.05)。SOD、cTnT、HS-CRP、CK-MB均参与了病毒性心肌炎的发病过程。

Objective ：To study viral myocarditis, superoxide dismutase （SOD） and myocarditis specific markers and its clinical significance. Methods：48 cases of children with viral myocarditis were for experimental group and 48 cases of healthy children were for control group. Cardiac troponin （ cTnT）, high sensitive C reactive protein （HS- CRP） ,creatine kinase isoenzyme （CK -MB） as well as SOD were detected in the two groups repectively, their correlations were also evaluated. Results：The experimental group CTnT, HS -CRP, and CK - MB levels were significantly higher than those in the control group （ P 〈 0.05 ） ,There was statisti- cal significance of SOD activity in the experimental group compared with the control group （ P 〈 0.01 ）. 3 weeks after the treatment, cTnT, HS - CRP, and CK - MB levels were significantly lower （ P 〈 O. 05 ）. The activity of SOD increased significantly （ P 〈 0. O1 ）, and negatively correlated with cTnT, HS - CRP, and CK - MB level （ P 〈 0.05 ）. Conclusion ： SOD, cTnT, HS - CRP and CK - MB were all involved in the pathogenesis of viral myocarditis.