甘油三酯水平升高与动脉粥样硬化性心血管疾病的关系的研究新进展

Research Advances of Relationship Between Triglyceride Level and Atherosclerotic Cardiovascular Disease

血浆甘油三酯(TG)主要存在于乳糜微粒(CM)和极低密度脂蛋白(VLDL)中,并与动脉粥样硬化性心血管疾病(CVD)密切相关。机体内富含甘油三酯的脂蛋白(TRL)含量可以反映血浆TG水平,其代谢过程异常可引起TG水平升高,进而影响CVD的发生发展。研究发现,TRL本身及其残粒通过促进血管内皮功能失调、泡沫细胞形成及诱发炎症反应参与动脉粥样硬化(As)的发生发展过程。因此,本文主要针对TG与CVD的关系及高TG致As机制的最新进展做一综述,以期推动TG在CVD中的研究,为CVD防治提供新的理论依据。

Plasma triglyceride （TG） exists mainly in chylomicron particles and very low density lipoprotein （VLDL）. Triglyceride-rich lipoprotein （TRL） in the body is on behalf of the level of TG in plasma,its metabolic process is affected by some factors such as diet,enzymes,transcription factors,gene mutation and microRNA. Metabolic disorders of TRL will cause high TG level. A large number of epidemiological studies have shown that TG level relates with atherosclerotic cardiovascular disease （CVD） closely. Therefore,this article focuses on the current views on relationship of TG and CVD and its proatherogenic mechanism,in order to make clear the important function and meaning of TG in the development of atherosclerosis and provide a new theoretical basis for the prevention and cure of CVD with TG-lowering therapy.