华北城市地区成人肺通气功能预计值方程

Predictive equations of lung function for adults in north China urban areas

目的建立华北城市地区成人肺通气功能的预计值方程式。方法对来自华北城市地区进行过基础体检符合健康成人条件的1200例(男性600例,女性600例)体检者测定用力肺活量(FVC)、第1秒用力呼气容积(FEV1)等5个常用肺通气指标,通过多元逐步回归求得各指标预计方程式,并与ECSC、Knudson等常用预计方程式比较预测值和实测值差异。结果肺功能指标中FVC、FEV1、FEF25%、FEF75%存在性别差异,FEV1/FVC无性别差异。多元逐步回归分析,男、女性肺功能指标FVC、FEV1、FEF 25%、FEF 25%均与身高呈正相关,与年龄呈负相关,而FEV1/FVC与身高及年龄均呈负相关,五项指标与体质量均无明显相关性。建立的肺功能指标的预计方程式,与其他预计方程式比较,本方程预计值与实测值差异最小。结论本研究建立的肺通气功能的预计方程式较适用于华北城市地区成人。

Objective To establish predictive equations of lung function for adults in urban areas in north China. Methods A survey was conducted in 600 male and 600 female healthy adults in the urban areas in north China. Five flow-volume test parameters were measured including forced vital capacity （FVC） and forced expiratory volume in one second （FEV1）. Stepwise multiple regression was carried out to establish the predicative equations for the parameters for male and female adults separately. The predicted values from these equations and those from other commonly used equations （such as ECCS equation and Knudson equation） were compared with the actual measurements in pulmonary function tests. Results Four flow-volume test parameters, namely FVC, FEV1, 25% forced expiratory flow （FEF25%）, and FEF75%, showed obvious differences between the male and female adults, while FEV1/FVC was not correlated with gender. Multiple regression analysis showed that FVC, FEV1, FEF25% and FEF75% were positively correlated with height and negatively with age, and FEV1/FVC was negatively correlated with both height and age. The parameters were not affected by body weight. The predicted values from our equations were doser to the actual measurements than those calculated from other equations. Conclusion The equations we established are more appropriate than the generally used equations for predicting lung functions in adults in north China urban areas.