胆囊切除术后综合征相关危险因素分析

Analysis of Risk Factors of Postcholecystectomy Syndrome

[摘要]目的探讨胆囊切除术后综合征发生的相关危险因素。方法回顾性分析我院2006年1月-2011年1月治疗的542例行胆囊切除术患者的临床资料，分别对可能与胆囊切除术后综合征发生相关的因素进行分析，采用单因素与多因素分析筛选出相关因素。结果542例患者中，142例发生胆囊切除术后综合征。单因素分析结果显示性别（P=0．026）、胆囊管残留过长（P=0．022）、Oddi括约肌狭窄（P=0．002）与胆囊切除术后综合征发生相关；多因素分析显示Oddi括约肌狭窄（RR=11．563，P=0．017）为胆囊切除术后综合征发生的独立危险因素。结论Oddi括约肌狭窄为胆囊切除术后综合征发生的独立危险因素。

Objective To explore the risk factors of postcholecystectomy syndrome. Methods A retrospective study had been done in 542 patients who underwent cholecystectomy between January 2006 and January 2011. Univariate analysis and logistic regression were used to determine the effect of multiple factors on postcholecystectomy syndrome. Results Of the 542 patients, 142 patients were identified as postcholecystectomy syndrome. Univariate analysis showed sex （P = 0. 026） , cystic duct remnant （ P = 0. 022） and stenosis or dyskinesia of the sphincter of Oddi（ P = 0. 002 ） were associated with postcholecystectomy syndrome. A multivariate logistic regression analysis revealed the factor most highly associated with postcholecystectomy syndrome was stenosis or dyskinesia of sphincter of Oddi （ RR = 11. 563, P = 0.017）. Conclusion Stenosis or dyskinesia of the sphincter of Oddi is an independent risk factor of postcholecystectomy syndrome.