43例垂体瘤术后成人生长激素水平调查

The Investigation of Postoperative Growth Hormone in 43 Adults of Pituitary Tumor

目的了解垂体瘤患者在接受治疗后生长激素的储备功能及生长激素缺乏与多种垂体激素缺乏之间的关系。方法以2008年5月至2013年7月间,以在河北省沧州市中心医院接受治疗的43位垂体瘤患者作为调查对象,进行胰岛素低血糖兴奋试验(ITT),分析生长激素(GH)、促性腺激素(Gn)、促甲状腺激素(TSH)、精氨酸加压素(AVP)和促肾上腺皮质激素(ACTH)的分泌功能。结果共入组43例垂体瘤患者,男性29例,女性14例,中位年龄为48岁。其中仅5例ITT实验兴奋后GH分泌正常,余38例均患严重的生长激素缺乏症,且表现出一种或一种以上的垂体激素缺乏症状。结论垂体瘤术后,生长激素缺乏症的发生率很高;患有一种或一种以上垂体激素缺乏的患者都会伴有生长激素缺乏症。

Objective To study the reserve function of growth hormone （ GH）, the incidence rate of a- duh growth hormone deficiency and its correlation factors in the postoperative patients with pituitary adenoma. Methods From May 2008 to July 2013, 43 patients with pituitary adenomas were included as respondents. In- sulin tolerance test （ITr）, growth hormone （GH）, gonadotropin（ Gn）, thyroid stimulating hormone （TSH）, arginine vasopressin hormone （AVP） and adrenocorticotropic hormone （ACTH） secretion function were tested. Results This study enrolled a total of 43 cases of pituitary tumor patients, 29 males and 14 females, whose median age was 48 years. Only 5 cases had normal GH secretion after the ITY experiments which made patients excited, and the remaining 38 cases were suffering from severe growth hormone deficiency, which showed one or more types of pituitary hormone deficiency symptoms. Conclusions There is a high incidence rate of adult growth hormone deficiency in the postoperative patients with pituitary adenoma. Adult growth hormone deficien- cy often occurs in the patients with one or more than one kind of pituitary hormone deficiency.