计算机模型和仿真在心脏病研究中的应用(续前)
摘要
在细胞层面，离子通道的改变通常对应于遗传性心律失常综合征，例如长QT综合征（long Q-T syndrome, LQTS）和Brugada综合征（Brugada syndrome，BrS），主要体现在编码心肌细胞离子通道的基因发生突变。Clancy和Rudy模拟了SCN 5 0A基因的KPQ基因突变（获得功能的基因突变）所导致的LQTS，模拟结果显示，基因突变导致的钠电流失活门多肽的改变中断钠电流失活，从而引起后期钠电流的产生。这导致了电动势时程的延长和QT间期的延长，从而形成LQTS。
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2013年第10期905-908,共4页
Chinese Journal of Hypertension
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