子宫腺肌病组织中PRL-3、VEGF的表达变化及意义

Expression changes of phosphatase of regenerating liver-3 and vascular endothelial growth factor in the adenomyosis

目的观察子宫腺肌病(AM)组织中促肝细胞再生磷酸酶-3(PRL-3)及血管内皮细胞生长因子(VEGF)的表达变化,并探讨其意义。方法选取30例AM患者异位内膜(异位组)、在位内膜组织(在位组),以及30例子宫肌瘤患者正常子宫内膜组织(对照组),采用免疫组化法检测各组织中PRL-3、VEGF的表达水平。结果 VEGF及PRL-3在异位组表达显著高于在位组及对照组(P均<0.01),且在在位组的表达高于对照组(P均<0.05)。异位组、在位组增生期与分泌期内膜中PRL-3的表达均高于同时相对照组(P均<0.05)。对照组中VEGF在分泌期内膜中的表达高于增生期(P<0.05)。PRL-3与VEGF在在位组中的表达呈正相关关系(r=0.439,P<0.05)。结论 PRL-3及VEGF在AM异位内膜中呈高表达,二者可能与AM的发病有关。

Objective To observe the expression changes of phosphatase of regenerating liver-3 （PRL-3） and vascular endothelial growth factor （VEGF） in adenomyosis （AM） tissues and to investigate the clinical significance.Methods The samples collected for this study were 30 cases of ectopic endometrium （ectopic group）,30 cases of eutopic endometrium（eutopic group）from patients with AM and 30 cases of control endometrium （control group）.The expression of PRL-3 and VEGF were measured by immunohistochemistry.Results The expression of PRL-3 and VEGF in ectopic group was increased as compared with that in eutopic and control groups; and eutopic group was higher than control group （all P ＜0.05）.The expression of PRL-3 in hyperplasia period and secretory period of the ectopic and eutopic groups was higher than that of the control group （all P ＜ 0.05）.In the control group,the expression of VEGF in secretory period was higher than in hyperplasia period （P ＜ 0.05）.In the eutopic group,the expression of PRL-3 was positively correlated with expression of VEGF （r =0.439,P ＜ 0.05）.Conclusion The high expression of PRL-3 and VEGF in ectopic and eutopic endometrium may be associated with the onset of AM.