ABO血型新生儿溶血病血清学检测与新生儿高胆红素血症的相关性

Correlation between serological test and neonatal hyperbilirubinemia in neonates with ABO hemolytic disease

目的:探讨ABO新生儿溶血病血清学试验检测结果与新生儿高胆红素血症发生率的关系。方法:在孕妇分娩前和新生儿出生后分别进行ABO、RhD血型鉴定。对母/子血型为O/A(B)、RhD(+)组合的375例新生儿进行新生儿溶血病血清学试验检测,调查其高胆红素血症的发生率,并与393例ABO血型相合新生儿进行对照。结果:ABO新生儿溶血病血清学试验阳性组新生儿高胆红素血症的发生率显著高于对照组(χ2=66.91,P<0.01)和试验阴性组(χ2=34.40,P<0.01)。血清学三项试验以放散试验敏感性最高(67.29%),DAT(93.28%)特异性最高。结论:ABO新生儿溶血病血清学试验结果对预判新生儿高胆红素血症发生有一定的临床意义,早期对母子ABO血型不合的新生儿进行血清学试验检测是早期诊断新生儿高胆红素血症的有效方法。

Objective: To explore the relationship between serological test results and incidence rate of neonatal hyperbilirubinemia in neonates with ABO hemolytic disease.Methods: ABO and RhD blood grouping were conducted before delivery and after birth; 375 neonates whose maternal and infantile blood blood type was O / A( B) and RhD( +) received serological test of neonatal hemolytic disease, the incidence rate of neonatal hyperbilirubinemia was surveyed,and the results were compared with 393 neonates with compatible ABO blood type.Results: The incidence rate of neonatal hyperbilirubinemia in positive serological test group was statistically significantly higher than those in control group( χ2= 66.91,P < 0.01) and negative serological test group( χ2= 34.40,P < 0.01); among three items of serological test,the sensitivity of elution test was the highest( 67.29%),and the specificity of DAT was the highest( 93.28%).Conclusion: The results of serological test of ABO neonatal hemolytic disease have a certain clinical significance in predetermining the occurrence of neonatal hyperbilirubinemia,conducting serological test early among the neonates with incompatible maternal-infantile ABO blood type is an effective method to early diagnose neonatal hyperbilirubinemia.