新生儿维生素D营养状况调查

Current status of vitamin D nutrition and Calcium /Phosphorus level in newborns

目的通过测定新生儿血清25-羟维生素D[25（OH）D]、甲状旁腺激素（PTH）、钙、磷浓度，了解兰州市新生儿维生素D营养状况，指导临床补充维生素D。方法选取2012年9～12月在兰州大学第一医院住院的90例新生儿为研究对象，早产儿30例，足月儿60例，采用酶联免疫法检测两组患儿生后10天内血清25（OH）D、PTH浓度，并分析两者之间的相关性；血清标本的钙、磷水平由贝克曼AU2700全自动生化分析仪测定。结果早产儿血清25（OH）D浓度为（21．9±2．5）nmol／L，显著低于足月儿（34．9±10．8）nmol／L，差异有统计学意义（P〈0．05）；早产儿血清町H浓度为（94．7±40．2）pg／ml，显著高于足月儿（56．1±30．0）pg／ml，差异有统计学意义（P〈0．05），新生儿血清25（oH）D水平与明H呈负相关；旱产儿血钙浓度为（2．1±0．3）mmob／L，低于足月儿（2．3±0．3）mmol／L，差异有统计学意义（P〈0．05）；早产儿血磷浓度为（1．8±0．7）mmoL／L，足月儿为（1．6±0．5）mmol／L，差异无统计学意义（P〉0．05）。结论兰州市新生儿普遍存在维生素D缺乏或不足的现象，应加强孕母和新生儿的维生素D补充。

Objective To study the nutritional status of serum 25-hydroxyvitamin D[25-（OH）D] , parathyroid hormone（PTH） , calcium and phosphorus concentration of the newborns in Lanzhou city to so as to provide reference data for the clinical practice of vitamin D supplementation. Methods Total of 90 neonates admitted to Lanzhou University First Hospital from September to December, 2012 were enrolled in the study, and the serum 25-（OH） D, PTH levels were determined with ELISA method. The correlation of 25-（OH） D and PTH was evaluated. Calcium and phosphorus concentration was measured using Beckman AU2700 automatic biochemical analyzer. Results The serum concentration of 25-（OH） D in premature infants was （21.9 ±2. 5 ） nmol/L, significantly lower than full-term infants （34. 9 ± 10. 8 ） nmol/L, P 〈 0.05. The serum concentration of PTH in premature infants was significantly higher than that of full-term infants [ （ 94. 7 ± 40. 2） pg/ml vs. （ 56. 1± 30. 0） pg/ml, P 〈 0.05 ]. 25-（OH） D and FFH were inversely correlated （P 〈 0.05）. The serum concentration of calcium in premature infants was higher than that of full-term infants [ （ 2. 1± 0. 3 ） mmol/L vs. （2.3 ± 0.3 ） mmol/L, P 〈 0. 05 ]. The serum concentration of phosphorus had no statistically significant different between premature infants and full-term infants （P 〉 0. 05 ）. Conclusions Vitamin D deficiency is common among newborns in Lanzhou. Vitamin D should be supplemented for pregnant women and newborns.