维生素D在哮喘发病机制中的作用

Vitamin D participates in the pathogenesis of asthma.

生素D除了参与钙磷代谢和调节骨骼稳态作用外，还具有调节机体免疫等广泛的生物学调节功能。维生素D不足使免疫细胞增殖和分化偏移而产生异常免疫反应。哮喘是由多种细胞（包括肥大细胞、嗜酸性粒细胞和T淋巴细胞）参与的慢性气道炎症，也是一种由遗传和环境因素共同作用的复杂多基因遗传病。近些年研究表明，维生素D缺乏会增加哮喘易感性和严重程度，与哮喘的遗传和非遗传因素共同参与哮喘的发病。

Vitamin D, with the function of regulating calcium-phosphorus metabolismand bone homeo-stasis ,plays important roles in the regulation of body immunity system. Vitamin D deficiency can cause abnormal proliferation and differentiation of immune cells,which lead to abnormal immune responses. Asthma is a chronic airway inflammation participated by a variety of cells including mast cells, eosinophils and T lymphocytes, It is also a complex polygenichereditary disease wiih the combined action of genetic and environmental factors. Re-cent studies have shown that vitamin D deficiency increased the susceptibility and severity of asthma, and it con-tributed to the development of asthma together with genetic and non-genetic factors.