摘要
MMP-9即基质金属蛋白酶-9，在人体多种组织均有表达。编码该蛋白酶的基因称MMP-9基因，该基因不仅在决定个体对某些疾病的易感性上起重要作用，而且其表达与某些疾病的发生、发展密切相关。牙周病为发生在牙周支持组织（牙龈、牙周膜、牙槽骨、牙骨质）的疾病。近年研究发现MMP-9基因表达及单核苷酸多态性（SNP）在牙周病发病机制中起到重要作用。
MMP-9 （Matrix metalloproteinase-9 ） is a type of proteinases expresses in various tissues. MMP-9 plays an important role in individual susceptibility to certain diseases. Its expression is closely associated with the development of certain diseases. Periodontal diseases occur in periodontal supporting tissues such as gingival, alveolar bone, periodontal ligament, cementum. In recent years, many studies have found that the ex-pression and its single nucleotide polymorphism of MMP-9 gene play an important role in the pathogenesis of periodontal diseases. This review provides summary the studies of MMP-9 and its role in the pathogeness of peri- odontal diseases.
出处
《国际免疫学杂志》
CAS
2013年第6期446-449,共4页
International Journal of Immunology
关键词
基质金属蛋白酶-9
牙周病
牙槽骨吸收
牙根吸收
Matrix metalloproteinase-9
Periodontal diseases
Alveolar bone resorption
Root resorption
