南川木波罗枝条的化学成分研究

Studies on Chemical Constituents Occurring in Twigs of Artocarpus nanchuanensis

目的:研究南川木波罗枝条的化学成分。方法:采用硅胶、Diaion HP20大孔吸附树脂、MCI gel CHP 20P树脂凝胶、Sephadex LH-20凝胶、ODS等柱色谱分离手段,对南川木波罗枝条的95%乙醇提取物进行化学成分的分离纯化,根据化合物的理化性质及光谱数据鉴定其结构。结果:分离了10个化合物,分别鉴定为diosgenin(1),prosapogenin of dioscin(2),progeninⅡ(3),薯蓣皂苷元-3-O-α-L-吡喃鼠李糖基(1→4)-α-L-吡喃鼠李糖基(1→3)-β-D-吡喃葡萄糖苷(4),7-oxositosterol acilglicosilado(5),咖啡酸乙酯(6),邻苯二甲酸二丁酯(7),松脂素(8),(7S,8S,8'R)-5,5'-二甲氧基落叶松树脂醇(9),棕榈酸(10)。结论:除化合物6,10外,其他化合物均为首次从桑科植物中分离得到。化合物4为首次以天然产物的形式从自然界获得。

Objective：To study the chemical constituents of twigs of Artocarpus nanchuanensis.Method：The constituents were isolated from 95% ethanol extraction of twigs of A.nanchuanensis by column chromatography over silica gel,Diaion HP20 macroreticular resin,MCI CHP 20P gel,Sephadex LH-20 gel,ODS gel,etc.Their structures were elucidated by analysis of physical chemical properties and spectral data.Result：Ten compounds were isolated and their structures were identified as diosgenin （1）,prosapogenin of dioscin （2）,progenin Ⅱ（3）,diosgenyl-3-O-α-L-rhamnopyranosyl （1→3）-[α-L-rhamnopyranosyl （1→4）]-β-D-glucoside （4）,7-oxositosterol acilglicosilado （5）,ethyl caffeate （6）,dibutylphthalate （7）,pinoresinol （8）,（7S,8S,8＇R）-5,5＇-dimethoxylariciresinol （9）,palmitic acid （10）.Conclusion：Except for compounds 6 and 10,the other compounds are reported from the family Moraceae for the first time.This is the first time that 4 has been reported as naturally occurring compound.