心痛逐瘀汤对不稳定型心绞痛患者血小板功能的影响

Effects of Xintong Zhuyu Decoction on Platelet Function in Patients With Unstable Angina Pectoris

目的:探讨心痛逐瘀汤对不稳定型心绞痛(UA)患者血小板及改善血管内皮的功能。方法:将78例UA患者按住院前后顺序分为观察组和对照组各39例。两组均给予常规治疗,对照组采用氯吡格雷片,75 mg·d-1,1次/d,口服。观察组采用心痛逐瘀汤,1剂/d,常规水煎分2次服用。两组疗程均为8周。检测治疗前后血小板聚集率(MPAR),血浆血小板α-膜颗粒蛋白(GMP-140)、血栓素B2(TXB2)及血浆内皮素(ET)水平,检测治疗前后血液流变学指标。结果:观察组疾病疗效总有效率为92.3%,优于对照组的74.4%(P<0.05);观察组心电图疗效总有效率82.1%,优于对照组的61.5%(P<0.05);治疗后观察组MPAR,GMP-140,TXB2及ET水平均低于对照组(P<0.01);治疗后观察组全血黏度(高切、低切)、血浆黏度、纤维蛋白原、红细胞聚集指数等血液流变指标的改善均优于对照组(P<0.01)。结论:心痛逐瘀汤能改善血小板聚集率,抑制血栓的形成,改善微循环状态,改善血管内皮功能,提高了疾病疗效和心电图疗效。

Objective：The purpose is to study of Xintong Zhuyu decoction on platelet function of unstable angina （UA） patients and the improvement of vascular endothelial function.Method：Seventy-eight cases of UA patients were randomly divided into observation group （39 cases） and control group （39 cases） according to the hospital order.The patients in both groups took general treatment.The patients in control group took clopidogrel tablets,75 mg/time,1 time/day,orally.The patients in observation group took Xintong Zhuyu decoction,0.5 dose/time,2 times/day,conventional water frying.The course treatment for both groups is 8 weeks.Platelet aggregation rate （MPAR）,the plasma platelet α-membrane particle protein （GMP-140）,thromboxane B2 （TXB2）,plasma endothelin （ET） levels and hemodynamic indexes will be test before and after the treatment.Result：The total curative effect of observation group was 92.3%,which is higher than 73.52% of the control group （P 〈 =.05）.The total curative effect of electrocardiogram of observation group was 82.1%,superior to 61.5% of the control group （P 〈0.05）.After the treatment,the levels of MPAR,GMP-140,TXB2 and ET of observation group were all lower than control group （P 〈 0.01）.The improvement of blood rheology indicators,including whole blood viscosity （high shear,low shear）,plasma viscosity,fibrinogen and red cell aggregation index,were better than control group （P 〈 0.01）.Conclusion：Xintong Zhuyu decoction can improve platelet aggregation rate,inhibit the formation of blood clots,improve microcirculation status and endothelial function and improve the curative effect and electrocardiogram curative effect.So it is worth promoting in clinical treatment.