阿莫西林／克拉维酸序贯疗法治疗婴儿社区获得性肺炎的疗效分析

目的观察阿莫西林／克拉维酸序贯疗法治疗婴儿社区获得性肺炎（CAP）的临床效果。方法将2011年1月至12月98例婴JDCAP分成两组，对照组45例给予阿莫西林／克拉维酸30mg／（kg一次）连续静脉滴注7—10d，观察组53例给予静脉滴注3～5d后改为阿莫西林／克拉维酸20～30rng／（kg-次），口服3-7d。结果对照组总有效率97．8％，观察组总有效率94-3％，两组差异无统计学意义（P〉0．05）。观察组不良反应及并发症发生率11．3％低于对照组33．3％（P〈0．01），抗生素费用（253．5±79．1）元低于对照组（473．6±90．6）元（P〈0．01），住院时间（5．4±2．7）d短于对照组（8．3±3．2）d（P〈0．01）。结论阿莫西林／克拉维酸序贯疗法是治疗婴JLCAr,安全有效、成本较低的方法。

Objective To observe the effect and cost of sequential antimicrobial therapy in treating infant community- acquired pneumonia （ CAP ） . Methods 98 infants with CAP from 2011 January to 2011 December were divided into two groups. The control group （ 45 cases ） was received amoxicillin/clavulanic acid 30mg/ （ kg.times ） continued vein intravenous drip therapy of 7-10 days, the observed group （ 53 cases ） was received intravenous infusion of 3-5 days to amoxicillin/ clavulanic acid 20-30mg/ （ kg.times ） oral administration of 3-7 days. Results The total effective rate was 97.8% in control group, and 94.3% in observed group （ X 2=0.12, P〉0.05 ） . The observed group of adverse reaction and complication rate （ 11.3% ） was lower than that of control group （ 33.3% ） （ X^2=7.00, P〈0.01 ） , and costs of antibiotics （ RMB 253.5 ± 79.1 yuan ） were lower than that of control group （ RMB 473.6 ± 90.6 yuan ） （ t=-12.84, P〈0.01 ） , and average days of being in hospital （ 5.4± 2.7d ） were shorter than that of control group （ 8.3 ± 3.2d ） （ t=4.87, P〈0.01 ） . Conclusion Sequential antimicrobial therapy on infant CAP is safe and effective with low cost.