摘要
经皮冠脉介入（PCI）是治疗冠心病重要而有效的手段，但围手术期仍有部分患者发生心脏事件（死亡、心肌梗死、再次血运重建），且PCI后5年随访中无心脏事件生存率仅为50％左右。本研究通过测定PCI前后不稳定型心绞痛患者炎性因子白介素-18（IL-18）和基质金属蛋白酶-9（MMP-9）血清水平，评价PCI对其的影响。1资料与方法1．1分组及危险因素调查1．1．1观察组：选择2006年11月～2008年12月在本院行PCI的241例不稳定型心绞痛患者，
Objective:To observe the effect of percutaneous coronary intervention(PCI)on blood levels of interleukin-18(IL-18)and matrix metalloproteinase-9(MMP-9)in patients with coronary heart disease(CHD). Method:241patients who underwent PCI from November 2006to December 2008were included in this study,and 109patients who received coronary angiography(CAA)during the same period were selected as controls.Serum levels of IL-18and MMP-9 were measured in the early morning of the procedure and at 24hours after the procedure,respectively.Results:During the same period,the serum levels of IL-18and MMP-9in patients with CHD were significantly higher than those in the controls(P<0.01).In patients with CHD,the serum levels of IL-18and MMP-9after the procedure were significantly higher than those before procedure(P<0.01).However,in control group the serum levels of IL-18 and MMP-9 after the procedure were not different from those before procedure(P>0.05).Conclusion:The result suggests that PCI can lead to a detectable increase of the levels of IL-18and MMP-9in patients with CHD.
出处
《微循环学杂志》
2013年第4期34-36,I0002,共4页
Chinese Journal of Microcirculation
