术前血清SCCA水平与宫颈鳞癌生物学行为的关系

Correlation of Preoperative SCCA Level with Biological Characteristics of Squamous Cervical Cancer

目的：探讨术前血清鳞状细胞癌抗原（Squamous cell carcinoma antigen ，SCCA ）与宫颈鳞癌的临床病理因素的关系。方法：对2010年1月-2012年12月在我院就诊的118例ⅠB～ⅡA期的宫颈鳞癌患者行术前血清SCCA水平检测，并结合其临床资料进行回顾性分析术前血清SCCA水平与宫颈鳞癌的临床病理特征的相关性。结果：118例宫颈鳞癌患者中检测的术前血清SCCA阳性为75例（63．6％），宫颈鳞癌患者术前血清SCCA水平与临床分期、肿瘤直径、肌层浸润深度及淋巴结转移相关（P＜0．05），而与年龄、分化程度及脉管癌栓未发现相关关系（P＞0．05）。结论：检测术前血清SCCA水平为其病情评估及判断预后提供新的手段，从而拟定出更加合理的个体化治疗方案。

Objective ：To investigate the correlation between the preoperative SCCA level and the clinicopathologic characteristics .Methods ：Preoperative serum SCCA detection was conducted in 118 patients with stage ⅠB~ ⅡA cervi-cal squamous cell carcinoma who were admitted to our hospiyal during a period from January 2010 to December 2012 , and a retrospective study of the cases in combination with the related clinical and pathological data was carried out .Re-sults ：Among 118 cases ,75 cases were found with positive SCCA ,significance correlation was found between the preop-erative SCCA level and clinical stage ,tumor size ,depth of stromal invasion ,lymph node metastasis（P〈0 .05）;no rela-tion was found between the pretreatment SCCA level and age ,pathologic grade and vascular invasion （P〉0 .05） .Con-clusion：Preoperative SCCA level plays an important role in condition assessment and evaluation of prognosis ,also it can develop a more rational individualized treatment plan .