粤西地区幽门螺杆菌对抗生素耐药分析

Analysis of Antibiotic Resistance of Helicobacter Pylori Isolated from Patients in Western Guangdong

目的:了解粤西地区幽门螺杆菌(H.pylori)对抗生素的耐药情况。方法:选择我院确诊的慢性浅表性胃炎或消化性溃疡患者600例,取胃窦黏膜组织进行H.pylori培养鉴定,采用Kirby-Bauer纸片扩散法对分离菌株进行药敏检测。结果:H.pylori分离培养阳性率为78.5%;H.pylori对甲硝唑、克拉霉素、左氧氟沙星及阿莫西林的耐药率分别是77.5%、20.4%、8.9%和3.2%。结论:粤西地区H.pylori根除治疗的抗生素首选阿莫西林和左氧氟沙星,避免使用甲硝唑,慎重使用克拉霉素。

Objective ：To investigate the antibiotic resistance of Helicobacter pylori （H .pylori） isolated from patients in Western Guangdong .Methods ：H .pylori was isolated from gastric mucosa biopsy specimens obtained from 600 pa-tients with chronic superficial gastritis or peptic ulcer disease in our hospital ,and then were cultured and identified . Additionally ,H .pylori strains were tested for drug resistance by Kirby-Bauer method .Results：The positive rate of iso-lated H .pylori strains was 78 .5% among 600 patients .The resistance rates for metronidazole ,clarithromycin ,levo-floxacin and amoxicillin were 77 .5% ,20 .4% ,8 .9% and 3 .2% respectively .Conclusion：The first-line antibiotic treat-ment for H .pylori infection in Western Guangdong should be amoxicillin and levofloxacin .In addition ,metronidazole was avoided in the treatment of H .pylori infection ,as well as clarithromycin which was used cautiously .