广西乙型肝炎病毒感染及肝功能情况调查

Survey on Hepatitis B Virus Infection and Live Function in Guangxi

目的：了解广西乙型肝炎病毒感染及肝功能损害情况，为乙型肝炎防治提供科学依据。方法按现况研究的原理，用三阶抽样法，在广西东、西、南、北、中各选定1个县，然后在每个县选择人口约1000人的自然村，对全人群采取静脉血，用酶联免疫吸附试验（ ELISA）检测HBsAg，用速率法检测丙氨酸氨基转移酶（ALT）。结果调查人群HBsAg阳性率为8．80％（400/4547），男性HBsAg阳性率高于女性（P＜0．01），不同年龄组HBsAg阳性率差异有统计学意义（P＜0．01），15岁以下年龄组HBsAg阳性率较低（4．79％），15～19岁明显上升，30～34岁达到最高峰（15．97％），35岁以上人群随年龄增加HBsAg阳性率呈下降趋势，但仍处在较高水平。 ALT异常率为9．83％（326/3318），男性ALT异常率高于女性（P＜0．01），19岁以前ALT异常率较低，20～69岁一直维持在较高水平，70岁以后开始下降。 HBsAg阳性人群ALT异常率高于HBsAg阴性人群（P＜0．01）。结论广西仍是乙型肝炎病毒高流行区，肝功能异常率偏高，应继续加强乙肝疫苗接种，做好肝病防治工作。

Objective To explore the situation of hepatitis B virus infection and live function in Guangxi and provide the scientific basis for the prevention and treatment of hepatitis B .Methods According to cross-sectional study and multistage sampling ,five counties were selected from eastern ,western ,southern ,northern ,and central Guan-gxi .A village with a population of about one thousand was selected from each county .The venous blood was collected from whole population.HBsAg was detected by enzyme-linked immune sorbent assay （ELISA） while alanine amin-otransferase （ ALT） was detected by performance rate method .Results The average positive rate of HBsAg in study population was 8.80%（400/4 547）.The positive rate of HBsAg in male was significantly higher than that in female P〈0 .01 ） .There were significant differences in the positive rate of HBsAg among groups of different ages （ P〈0 .01 ） . The groups aged 15 years and younger had a lower positive rate of HBsAg （4.79%）.The positive rates of HBsAg in-creased significantly among groups aged 15-19 years old,and reached a peak of 15.97%among groups aged 30-34 years old.It declined gradually among people aged 35 years and older,but was still at a higher level.The abnormal rate of ALT was 9.83%（326/3 318）.The abnormal rate of ALT in male was significantly higher than that in female （P〈0.01）.The abnormal rate of ALT was low in people aged 19 years and younger,and was maintained at a high level among people aged 20-69 years old .It declined among people aged 70 years and older .The abnormal rate of ALT among people with positive HBsAg was higher than that with negative HBsAg （P〈0.01）.Conclusion Guangxi is still a region with high incidence rate of hepatitis B virus ,and the rate of abnormal liver function is high .It should be keeping strengthening the vaccination of hepatitis B as well as prevention and treatment of liver disease .