期刊文献+

缺血修饰白蛋白在急性脑血管病中的动态变化 被引量:4

下载PDF
导出
摘要 目的观察缺血修饰白蛋白(IMA)在急性脑血管病的动态变化。方法采用酶联免疫吸附测定法(ELISA)检测脑梗死52例、脑出血34例、短暂性脑缺血发作38例和健康对照组40例的血清IMA浓度。分别对急性脑血管病患者和健康对照组4个时间点(发病或体检后6 h、12 h、24 h、48 h)的IMA水平进行检测。结果 4组不同时间点的IMA水平比较,差异有统计学意义(P<0.05)。脑梗死、脑出血、短暂性脑缺血发作组6 h IMA水平均高于对照组(P<0.05),且脑梗死>脑出血>短暂性脑缺血发作组(P<0.05);脑出血组6 h、12 h、24 h、48 h组内比较,差异无统计学意义(P>0.05);短暂性脑缺血发作组发病12 h IMA与对照组比较,差异无统计学意义(P>0.05)。结论 IMA可能为急性脑血管病的鉴别诊断提供参考。
出处 《广西医学》 CAS 2013年第11期1517-1518,1521,共3页 Guangxi Medical Journal
  • 相关文献

参考文献11

二级参考文献34

  • 1Lippi G, Montagnana M, Guidi and ischemia modified albumin response to ischemia [J]? Int 410-411.
  • 2Longa E Z, Weinstein P R, Carlson S, et al. Reversible middle cerebral artery occlusion with-out craniectomy in rats [J]. Stroke, 1989,20( 1 ) : 84-91.
  • 3Zhan C, Yang J. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats [J]. Pharmacol Res,2006,53(3):303-309.
  • 4Bar-Or D, Lau E, Winkler J V. A novel assay for cobalt- albumin binding and its potential as a marker for myocardial ischemia-a preliminary report [J]. J Emerg Med,2000,19(4): 311-315.
  • 5Uno M, Kitazato K T, Nishi K, et al. Raised plasma oxidised LDL in acute cerebral infarction [J]. J Neural Neurosurg Psychiatry, 2003,74 ( 3 ) : 312-316.
  • 6Huang P, Lo L H, Chen Y C, et al. Serum free hemoglobin as a novel potential biomarker for acute isehemie stroke [J]. J Neurol, 2009,256 (4) : 625-631.
  • 7Gunduz A, Turkmen S, Turedi S, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric isehemia [J]. Acad Emerg Med,2009,16(6) :539-543.
  • 8Refaai M A, Wright R W, Parvin C A, et al. Ischemia- modified albumin increases after skeletal muscle ischemia during arthroscopie knee surgery [J ]. Clin Chim Acta, 2006, 366(1-2) : 264-268.
  • 9Turedi S, Gunduz A, Mentese A, et al. Value of ischemia- modified albumin in the diagnosis of pulmonary embolism [J]. Am J Emerg Med, 2007,25 (7) : 770-773.
  • 10Kil H Y,J Cereb Blood Flow Metab,1996年,16卷,100页

共引文献46

同被引文献31

  • 1肖倩.缺血修饰白蛋白的研究进展和临床应用[J].实用中西医结合临床,2005,5(5):85-87. 被引量:8
  • 2中华神经科学会.各类脑血管疾病诊断要点[J].临床荟萃,1988,29:367 - 368.
  • 3Apple FS,Wu AH,Mair J, et al. Future biomarkers for de- tection of ischemia and risk stratification in acute coronary syndrome[J]. Clin Chem, 2005,51(6) : 810-824.
  • 4Worster A, Devereaux PJ, Heels- Ansdell D, et al. Capabili- ty of ischemia modified albumin to predict serious cardiac outcomes in the short term among patients with potential a- cute coronary syndromel-J]. CMAJ, 2005, 172 (13) : 1685- 1690.
  • 5Lippi G, Montagnana M, Salvagno GL, et al. Potential valuefor new diagnostic markers in the early recognition of acute coronary syndromes[J]. CJEM, 2006,8 (1) : 27-31.
  • 6Abboud H, Labreuche J, Meseguer E, et al. Ischemia- modi- fied albumin in acute stroke[J]. Cerebrovasc Dis, 2007,23 (2-3) : 216-220.
  • 7Gunduz A, Turedi S, Mentese A, et al. Ischemia- modified albumin levels in cerebrovaseular accidents [J]. American Journal of Emergency Medicine, 2008,26 (8) : 874-878.
  • 8Sinha MK, Roy D, Gaze DC, et al. Role of " ischemia modi- fied albumin" , a new biochemical marker of myocardial is- chaemia,in the early diagnosis of acute coronary syndromes I J]. Emerg Med J,2004,21 (1):29 -34.
  • 9Hjortshcj S, Kristensen SR, Ravkilde J. Diagnostic value of ischemia-modified albumin in patients with suspected acute coronary syndrome [ J ]. Am J Emerg Med, 2010,28 ( 2 ) : 170 - 176.
  • 10Talwalkar SS, Bon Homme M, Miller JJ, et al. Ischemia mod- ified albumin, a marker of acute ischemic events: a pilot study[J]. Ann Clin Lab Sci,2008,38(2) :132 -137.

引证文献4

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部