腹型肥胖个体血浆obestatin水平研究

The Plasma Levels of Obestatin in Abdominal Obesity Subjects

目的探讨腹型肥胖患者obestatin的血浆水平及与腰围的相关性。方法入选腹型肥胖组患者50例(男性腰围≥85cm,女性腰围≥80cm),及正常对照组20例(男性腰围<85cm,女性腰围<80cm,24 kg/m2>BMI≥18.5 kg/m2)。应用放射免疫分析法测定血浆obestatin及血清胰岛素水平。血清血脂水平采用自动生化分析仪进行酶法测定。胰岛素抵抗采用胰岛素抵抗指数(HOMA-IR)评定。结果腹型肥胖个体均表现出高的HOMA-IR、血清胆固醇及甘油三酯水平及低的高密度脂蛋白水平。与正常对照组相比,腹型肥胖组个体的血浆obestatin水平有所下降。在腹型肥胖的个体中,血浆obestatin水平与腰围及体重指数呈负相关。结论腹型肥胖组的血浆obestatin水平明显降低,而且obestatin水平与腰围呈负相关,提示obestatin与脂肪分布及腹型肥胖的发生有关。

Objective To explore the relationship between plasma obestatin concentrations in abdominal obesity subjects and waist circumference （WC）. Methods The present study comprised 2 groups, 50 Chinese abdomi- nal obesity subjects （waist circumference of men ≥85cm,waist circumference of women ≥80cm）, 20 age- matched normal subjects （waist circumference of men 〈 85cm,waist circumference of women 〈 80cm, BMI≥ 24kg/m2 ） were included. The fasting plasma levels of obestatin and insulin were measured by RIA. Insulin re- sistance was calculated by the homeostasis model of assessment for insulin resistance （HOMA-IR） approach. Results Subjects with abdominal obesity displayed higher HOMA-IR, serum total cholesterol and triglyceride compared to normal control. The plasma obestatin concentrations in abdominal obesity group were lower com- pared to normal control. The plasma obestatin concentrations in abdominal obesity subjects were negatively re- lated with WC and BMI. Conclusion The results in this study indicate that the obestatin might be important in distribution of body fat and development of abdominal obesity.