β射线照射治疗增生性瘢痕患者血清肿瘤坏死因子的变化及意义

Changes of Serum TNF-α Levels in Patients with Hypertrophic Scars After β-ray Treatment and Its Significance

目的为了解β射线治疗增生性瘢痕患者的疗效及肿瘤坏死因子(TNF-α)在照射治疗前、后的动态变化。方法148例增生性瘢痕患者中84例给予β射线敷贴治疗,40例给予激光治疗,24例不接受任何治疗。记录患者治疗前及治疗第1、2、3个疗程后,疗效及血清TNF-α浓度。并比较不同组之间治疗效果及TNF-α浓度差异。结果 42例患者经β射线敷贴治疗后治愈率83.3%、有效率100%;对照组治愈率30.0%、有效率55.0%,两组差异有统计学意义(P<0.01)。β射线治疗的患者血清TNF-a浓度逐渐下降,差异有统计学意义(P<0.05,P<0.01)。而对照组患者治疗前后血清TNF-a浓度无明显变化,差异无统计学意义(P>0.05)。结论β射线皮肤敷贴器照射能有效地治疗增生性瘢痕。随着增生性瘢痕的治愈,血清TNF-α浓度逐渐下降,为临床提供有效的理论依据。

Abstract：Objective To explore the dynamic changes of serum TNF-α in patients with hyperplastic scar before and after β-ray irradiation treatment. Methods 148 patients with hyperplastic scar were involved in this study, 84 cases were given β-ray treatment, 40 cases were given laser treatment, and 24 patients were not received any treatment. The serum TNF-α levels for each patient before and after 1, 2 and 3 period of treatment were measured. Results The cure rate in 84 patients and control groups with [3-ray treatment were 83.3% and 30.0% ; and effective rate were 100% and 55.0%, respectively （P 〈 0. O1 ）. The serum TNF-o~ levels in pa- tients with β-ray treatment were gradually decline, and had statistically significant compared with other groups （ P 〈 0.05 ）. There was no statistically difference on serum TNF-α levels in control group before and after treat- ment （ P 〉 0.05 ）. Conclusion The 1β-r ray contact therapy is effective treatment method for hyperplastic scars. The serum TNF-α levels might be used as a clinical indicator of effect judgment in β-r ray irradiation treatment of treatment of hyperplastic scars.