糖尿病胃轻瘫临床疗效的评价方式

Methods for clinical evaluation of diabetic gastroparesis

新药的探索与研究离不开有效的临床疗效评价方法.目前对于糖尿病胃轻瘫的临床疗效评价主要是对胃排空的评估、患者对疾病严重度的主观评估以及从发病因素改善方面的评估,然而目前胃排空检查方法缺乏临床广泛适用性、患者主观评估缺乏统一标准、糖尿病胃轻瘫发病机制并不明确成为寻找糖尿病胃轻瘫有效的临床疗效评价所面临的主要问题.本文通过查阅国内外大量文献,对这些问题进行了综述、评定以及展望,以期对糖尿病胃轻瘫的临床实验研究有一定帮助.

An effective clinical assessment method is necessary for the development of new drugs. Currently, main methods for clinical evaluation of diabetic gastroparesis （DGP） include evaluation of gastric emptying, patients’ subjective evaluation of disease severity and the change in pathogenic factors. However, there are many problems that need to address; the methods for the evaluation of gastric emptying have not been widely used, there is no uniform standard for the patients’ subjective evaluation, and the pathogenic factors for DGP are not completely clear. In this article we will review the methods for clinical evaluation of DGP, with the emphasis on the above problems.