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胰岛自身抗体检测在2型糖尿病视网膜病变中的意义

Significance of detection of islet autoantibodies in evaluating diabetic retinopathy of patients with type 2 diabetes mellitus
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摘要 目的探讨胰岛自身抗体检测在2型糖尿病(T2DM)视网膜病变发生发展中的意义。方法根据眼底荧光造影检查,将211例T2DM患者分为背景期视网膜病变(A组)、增殖期视网膜病变(B组)和无视网膜病变(C组)三组。检测血清胰岛细胞抗体(ICA)、谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗原2抗体(IA-2A)、胰岛素抗体(IAA)的阳性率及糖化血红蛋白(HbA1c)水平。结果 A、B组GADA阳性率高于C组(P<0.01),且B组GADA阳性率高于A组(P<0.05);C组ICA阳性率高于B组(P<0.01);A、B组HbA1c水平高于C组(P<0.01),且B组的HbA1c水平高于A组(P<0.01)。结论胰岛自身抗体检测及血糖控制状况有助于评估T2DM视网膜病变程度。 Objective To investigate the significance of islet autoantibodies in evaluating the occurrence and development of diabetic retinopathy in the patients with type 2 diabetes mellitus (T2DM). Methods On the basis of cheracteristics seen on the fundus fluorescent imaging, 211 T2DM patients were divided into three groups of A, B and C. Serum islet cell antibody(ICA), glutamic acid decarboxylase antibody(GADA), islet antigen-2 antibody (IA-2A) and islet autoantibody (IAA) and glycosylated hemoglobinAlc (HbAlc) were detected and compared among three groups. Results Positive rate of GADA in groups of A and B were higher than that in group C(P〈0. 01), which was higher in group B than that in group A(P〈0. 05). Positive rate of ICA in group C was higher than that in group B(P〈0. 01). The HbAlc was higher in groups of A and B than that in goup C, which was higher in group B than that in group A(P〈0. 01). Conclusion Detection of islet autoantibodies and glycemic control are helpful for evaluating and predicting the severity of diabetic retinopathy in T2DM patients.
作者 王蕾 刘步云
出处 《江苏医药》 CAS 北大核心 2013年第21期2562-2564,共3页 Jiangsu Medical Journal
关键词 2型糖尿病 糖尿病视网膜病变 胰岛自身抗体 Type 2 diabetes mellitus Diabetic retinopathy Islet autoantibody
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