甲亢患者25-羟-维生素D3代谢状况的变化

The change in metabolic status of serum 25-hydroxy-vitamin D3 in patients with hyperthyroidism

目的探讨甲状腺机能亢进症(甲亢)患者25-羟-维生素D3[25(OH)D3]的代谢状况。方法甲亢患者118例分为甲亢伴肝功能损害组(A组,58例)和甲亢无肝功能损害组(B组,60例)。健康体检者50名为对照(C)组。ELISA法测定血清25(OH)D3;放射免疫法测定血清甲状腺激素。同时检测血清总胆红素(TBil)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及血清钙、磷水平。结果 A组血清25(OH)D3水平明显低于B、C组(P<0.01)。血清25(OH)D3与TBil和AST呈负相关(P<0.01和P<0.05)。结论甲亢伴肝损害患者血25(OH)D3明显降低,提示25(OH)D3下降可能与肝功能异常相关。

Objective To investigate the metabolic status of serum 25-hydroxy-vitamin D3125 （OH） D3] in the patients with hyperthyroidism. Methods A total of 118 patients with hyperthyroidism was divided into two groups of A（58 cases with liver damage） and B（60 cases without liver dysfunction）. Serum 25 （OH）D3 was measured by ELISA. The thyroid hormones were examined by radioimmunoassay. Serum total biliruhin（TBil）, aspartate amino transferase（AST）, alanine amino transferase（ALT）, calcium and phosphorus were examined as well. Results Compared to groups of Cand B, serum level of 25 （OH）D3 of group A was lower（P（0. 01）. Serum level of 25 （OH）D3 was negatively correlated with that of TBil and AST（P〈0. 01 and P〈0. 05）. Conclusion Serum level of 25 （OH）D3 is reduced in the patients with hyperthyroidism associated with liver damage, which indicates that a decreased serum level of 25 （OH）D3 may be related to the abnormal liver function in the patients with hyperthyroidism.